11. (Journal Article): The beta cell transcription factors and development of the pancreas.

Sander M, German M
 
ABSTRACT: The pancreatic beta cell is the major source of circulating insulin in adult mammals. In the multistep process of insulin synthesis it is initiation of transcription that restricts...

12. (Journal Article): Formation of insulin positive cells in implants of human pancreatic duct cell preparations from young donors.

Bogdani M, Lefebvre B, Buelens N, Bock T, Pipeleers-Marichal M, Int Veld P, Pipeleers D
 
ABSTRACT: AIMS/HYPOTHESIS: Pancreatic ducts are considered as potential sites for neogenesis of beta cells. In vitro studies have reported formation of islets from postnatal human and rodent...

13. (Journal Article): C-peptide enhances insulin-mediated cell growth and protection against high glucose induced apoptosis in SH-SY5Y cells.

Li Z-G, Zhang W, Sima AAF
 
ABSTRACT: BACKGROUND: We have previously reported that C-peptide exerts preventive and therapeutic effects on diabetic neuropathy in type 1 diabetic BB/Wor-rats and that it prevents duration...

14. (Journal Article): Pancreas: how to get there from the gut?

Edlund H
 
ABSTRACT: All pancreatic cell types derive from the same endodermal dorsal and ventral anlage that grow together to form the definitive pancreas. A number of distinct transcription factors o...

15. (Journal Article): Prolonged exposure of human beta cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation.

Ling Z, Pipeleers DG
 
ABSTRACT: Human beta cells can be maintained in serum-free culture at 6 mmol/liter glucose, with 80% cell recovery and preserved glucose-inducible functions after 1 wk. Between 0 and 10 mmol...

16. (Journal Article): Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells.

Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM
 
ABSTRACT: Insulin-expressing beta cells, found in pancreatic islets, are capable of generating more beta cells even in the adult. We show that fibroblast-like cells derived from adult human ...

17. (Journal Article): Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas.

Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A, Levine F
 
ABSTRACT: Pancreatic cell lines are useful for basic studies of pancreatic biology and for possible application to cell transplantation therapies for diabetes. A retroviral vector expressing...

18. (Journal Article): Formation of insulin-positive cells in implants of human pancreatic duct cell preparations from young donors.

Bogdani M, Lefebvre V, Buelens N, Bock T, Pipeleers-Marichal M, In't Veld P, Pipeleers D
 
ABSTRACT: AIMS/HYPOTHESIS: Pancreatic ducts are considered as potential sites for neogenesis of beta cells. In vitro studies have reported formation of islets from postnatal human and rodent...

19. (Journal Article): Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

Halban PA
 
ABSTRACT: Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration ...

20. (Journal Article): {alpha}L integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium

Huang M, Matthews K, Siahaan TJ, Kevil CG
 
ABSTRACT: Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet beta cell destruction. We examined integrin requirements and specific inhibition of integrin...