171. (Journal Article): Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells.

Zalzman M, Gupta S, Giri R, Berkovich I, Sappal BS, Karnieli O, Zern MA, Fleischer N, Efrat S
 
ABSTRACT: Beta-cell replacement is considered to be the most promising approach for treatment of type 1 diabetes. Its application on a large scale is hindered by a shortage of cells for tran...

172. (Journal Article): Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human is-lets.

Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, Perfetti R
 
ABSTRACT: The peptide hormone, glucagon-like peptide 1 (GLP-1), has been shown to increase glucose-dependent insulin secretion, enhance insulin gene transcription, expand islet cell mass, an...

173. (Journal Article): Treatment of type 1 diabetes mellitus with DAB486-IL2, a toxin conjugate witch targets activated T-lymphocytes

Boitard C, Timsit J, Assan R, Mogenet A, Debussche X, Kaloustlan E, Attali JR, Chanson P, Chatenoud L, Woodworth T, et al.
 
ABSTRACT: Evidence point to autoreactive T-Iymphocytes in the pathogenesis of insulin-¬dependent diabetes mellitus (IDDM). Treatment with Cyclosporin A (7.5-10 mg/kg/d) of IDDM patients ind...

174. (Journal Article): SUMO wrestling with type 1 diabetes.

Li M, Guo D, Isales CM, Eizirik DL, Atkinson M, She JX, Wang CY
 
ABSTRACT: Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes ...

175. (Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
 
ABSTRACT: Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...

176. (Journal Article): Long-term Immunosuppression, Without Maintenance Prednisone, After Kidney Transplantation

Matas AJ, Kandaswamy R, Humar A, Payne WD, Dunn DL, Najarian JS, Gruessner RW, Gillingham KJ, McHugh LE, Sutherland DE
 
ABSTRACT: BACKGROUND:: Concern exists that prednisone-free maintenance immunosuppression in kidney transplant recipients will increase acute and/or chronic rejection. METHODS:: From October ...

177. (Journal Article): Expression of calbindin-D(28k) in a pancreatic islet beta-cell line protects against cytokine-induced apoptosis and necrosis.

Rabinovitch A, Suarez-Pinzon WL, Sooy K, Strynadka K, Christakos S
 
ABSTRACT: Cytokines produced by immune system cells that infiltrate pancreatic islets are candidate mediators of islet beta-cell destruction in autoimmune (type 1) diabetes mellitus. Because...

178. (Journal Article): Altered calbindin mRNA expression and calcium regulating hormones in rat diabetic pregnancy.

Hamilton K, Tein M, Glazier J, Mawer EB, Berry JL, Balment RJ, Boyd RD, Garland HO, Sibley CP
 
ABSTRACT: Offspring of rats with diabetes mellitus are at risk of reduced calcium and bone mineral content. Altered expression of the maternal calcium binding proteins, calbindin-D(9K) and c...

179. (Journal Article): Aberrant patterns of cellular communication in diabetes-induced embryopathy in rats: II, apoptotic pathways.

Reece EA, Ma XD, Zhao Z, Wu YK, Dhanasekaran D
 
ABSTRACT: OBJECTIVE: The objective was to test the hypothesis that hyperglycemia-induced injury of yolk sac cell membranes is associated with disruption of cellular apoptotic signaling pathw...

180. (Journal Article): Effect of diabetes mellitus on rat placenta cellularity.

Husain SM, Frost R, Mughal ZM
 
ABSTRACT: Transcellular placental maternofetal flux of calcium and magnesium is reduced in diabetic pregnancy in the rat which might be due to changes in placental cellularity. In order to i...