261. (Journal Article): A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity

Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh B
 
ABSTRACT: We have established a novel CD4 and CD8 double-positive CD25+ T regulatory (Treg) clone, MT-5B, from lymph nodes of type 1 diabetes prone non-obese diabetic (NOD) mice immunized wi...

262. (Journal Article): Autoimmune Diabetes: Ongoing Development of Immunological Intervention Strategies Targeted Directly Against Autoreactive T Cells

Sia C
 
ABSTRACT: It is well known that autoimmunity associated with the onset of insulin-dependent diabetes mellitus (IDDM) involves the generation of autoreactive T and B cells. The findings that ...

263. (Journal Article): ENPP1 K121Q Polymorphism is not Related to Type 2 Diabetes Mellitus, Features of Metabolic Syndrome, and Diabetic Cardiovascular Complications in a Chinese Population

Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ, Lee YJ
 
ABSTRACT: BACKGROUND: Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. A DNA polymorphism i...

264. (Journal Article): Gene regulatory factors in pancreatic development.

Jensen J
 
ABSTRACT: The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin-producing beta-cells normall...

265. (Journal Article): Differential role of programmed death-1 ligand and programmed death-2 ligand in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis.

Zhu B, Guleria I, Khosroshahi A, Chitnis T, Imitola J, Azuma M, Yagita H, Sayegh MH, Khoury SJ
 
ABSTRACT: Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances autoimmune disease ...

266. (Journal Article): Cell replacement therapy for type 1 diabetes.

Efrat S
 
ABSTRACT: Replacement of the insulin-producing pancreatic islet beta cells represents the ultimate treatment for type 1 diabetes. Recent advances in islet transplantation underscore the urge...

267. (Journal Article): Alterations in the renal elastin-elastase system in Type 1 diabetic nephropathy identified by proteomic analysis.

Thongboonkerd V, Barati MT, McLeish KR, Benarafa C, Remold-O'Donnell E, Zheng S, Rovin BH, Pierce WM, Epstein PN, Klein JB
 
ABSTRACT: Diabetes now accounts for >40% of patients with ESRD. Despite significant progress in understanding diabetic nephropathy, the cellular mechanisms that lead to diabetes-induced r...

268. (Journal Article): Visceral Obesity and Hemostatic Profile in Patients with Type 2 Diabetes: The Effect of Gender and Metabolic Compensation

Kozek E, Katra B, Malecki M, Sieradzki J
 
ABSTRACT: BACKGROUND: Type 2 diabetes (T2DM) patients are characterized by a very high risk of cardiovascular diseases. Among the factors that are responsible for this phenomenon are abdomin...

269. (Journal Article): The Relationship between Dietary Habits, Blood Glucose and Insulin Levels among People without Cardiovascular Disease and Type 2 Diabetes; The ATTICA Study

Panagiotakos DB, Tzima N, Pitsavos C, Chrysohoou C, Papakonstantinou E, Zampelas A, Stefanadis C
 
ABSTRACT: BACKGROUND: Diet has long been associated with a risk of insulin resistance and poor glycemic control. We sought to investigate the association between food groups and indices of g...

270. (Journal Article): Susceptibility gene discovery for common metabolic and endocrine traits

McCarthy MI
 
ABSTRACT: Almost all major causes of ill-health and premature death in human societies worldwide - including cancer, cardiovascular disease, diabetes and many infectious diseases - are, at l...