331. (Journal Article): Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

Chatenoud L
 
ABSTRACT: Major progress has been made over the last 10 years in understanding the immune mechanisms underlying autoimmune Type I (insulin-dependent) diabetes mellitus. It seems that immunot...

332. (Journal Article): Dynamics of beta-cell mass in the growing rat pancreas.

Finegood DT, Scaglia L, Bonner-Weir S
 
ABSTRACT: The growth and development of the endocrine pancreas has been studied for many years, but questions remain concerning the regulation of the mass of insulin-producing beta-cells bot...

333. (Journal Article): Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas.

Humphrey RK, Bucay N, Beattie GM, Lopez A, Messam CA, Cirulli V, Hayek A
 
ABSTRACT: Studies using adult human islets and mouse embryonic stem cells have suggested that the neurepithelial precursor cell marker nestin also identifies and can be used to purify beta-c...

334. (Journal Article): Attenuation of FGF signaling in mouse beta-cells leads to diabetes.

Hart AW, Baeza N, Apelqvist A, Edlund H
 
ABSTRACT: Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many organs, including the developing pancreas. Here we show ...

335. (Journal Article): B Cells in Autoimmune Diabetes

Wong FS, Wen L
 
ABSTRACT: Autoantibodies have been used as good markers for the prediction of future development of type 1 diabetes mellitus (T1DM), but are not thought to be pathogenic in this disease. The...

336. (Journal Article): Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-κB Activity in Embryos

Mammon K, Keshet R, Savion S, Pekar O, Zaslavsky Z, Fein A, Toder V, Torchinsky A
 
ABSTRACT: BACKGROUND: Mechanisms underlying diabetes-induced fetal growth retardation remain largely undefined. Two events such as the persistent activation of apoptosis or suppression of ce...

337. (Journal Article): TNF-alpha acts to prevent occurrence of malformed fetuses in diabetic mice.

Torchinsky A, Gongadze M, Orenstein H, Savion S, Fein A, Toder V
 
ABSTRACT: AIMS/HYPOTHESIS: Activation of apoptosis in embryos is thought to be a key event in the pathogenesis of diabetes-induced embryopathies such as early embryonic death and inborn stru...

338. (Journal Article): Sustained proliferation of PDX-1 (+) cells derived from human islets.

Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A
 
ABSTRACT: Ex vivo expansion of human beta-cells is an important step toward the development of cell-based insulin delivery systems in type 1 diabetes. Here, we report that human pancreatic e...

339. (Journal Article): Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P
 
ABSTRACT: The homeodomain protein PDX-1 is critical for pancreas development and is a key regulator of insulin gene expression. PDX-1 nullizygosity and haploinsufficiency in mice and humans ...

340. (Journal Article): Insulin secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F
 
ABSTRACT: Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell cl...