301. (Journal Article): Susceptibility gene discovery for common metabolic and endocrine traits

McCarthy MI
 
ABSTRACT: Almost all major causes of ill-health and premature death in human societies worldwide - including cancer, cardiovascular disease, diabetes and many infectious diseases - are, at l...

302. (Journal Article): Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young

Fajans SS, Bell GI, Polonsky KS
 
ABSTRACT: Maturity-onset diabetes of the young (MODY) is a clinically heterogeneous group of disorders characterized by nonketotic diabetes mellitus, an autosomal dominant mode of inheritanc...

303. (Journal Article): Presence of diabetes-inhibiting, glutamic acid decarboxylase-specific, IL-10-dependent, regulatory T cells in naive nonobese diabetic mice.

You S, Chen C, Lee WH, Brusko T, Atkinson M, Liu CP
 
ABSTRACT: Immunization of NOD mice with autoantigens such as glutamic acid decarboxylase (GAD) 221-235 peptide (p221) can induce Ag-specific CD4(+) T regulatory (Tr) cells. However, it is un...

304. (Journal Article): In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes.

Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA
 
ABSTRACT: The low number of CD4+ CD25+ regulatory T cells (Tregs), their anergic phenotype, and diverse antigen specificity present major challenges to harnessing this potent tolerogenic pop...

305. (Journal Article): Tolerance Induction and Endogenous Regeneration of Pancreatic Beta-Cells in Established Autoimmune Diabetes

Sia C, Homo-Delarche F
 
ABSTRACT: Studies aimed at the understanding of the multifactorial development of autoimmune diabetes have made substantial contributions toward elucidating the molecular mechanisms that ope...

306. (Journal Article): Entero-insular axis and diabetes mellitus.

Creutzfeldt W
 
ABSTRACT: 1. The incretin effect (i.e. the difference between the insulin response after oral and i.v. glucose) is reduced in type 2 diabetes although GIP secretion is normal or exaggerated....

307. (Journal Article): Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects.

Nathan DM, Schreiber E, Fogel H, Mojsov S, Habener JF
 
ABSTRACT: OBJECTIVE--Whether glucagonlike peptide-I-(7-37) (GLP-I-[7-37]), a naturally occurring intestinal peptide, is insulinotropic in nondiabetic and non-insulin-dependent (type II) diab...

308. (Journal Article): Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.

Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Tsukiyama K, Suzuki H, Kawasaki Y, Shimodaira M, Matsuoka K, Shibata T, Kasai Y, Maekawa T, Shapiro J, Tanaka K
 
ABSTRACT: Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a succ...

309. (Journal Article): Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site.

Carlsson PO, Palm F, Andersson A, Liss P
 
ABSTRACT: In this study, we syngeneically transplanted islets to three different implantation sites of diabetic and nondiabetic rats, then 9-12 weeks later we measured the blood perfusion an...

310. (Journal Article): Familial clustering of diabetic kidney disease. Evidence for genetic susceptibility to diabetic nephropathy

Seaquist ER, Goetz FC, Rich S, Barbosa J
 
ABSTRACT: Diabetic nephropathy develops in less than half of all patients with diabetes. To study heredity as a possible risk factor for diabetic kidney disease, we examined the concordance ...