421. (Journal Article): Modulating the Autoimmune Response in Type 1 Diabetes: A Report on the 64th Scientific Sessions of the ADA, June 2004, Orlando, FL, USA

Achenbach P, Fuchtenbusch P
 
ABSTRACT: Type 1 diabetes mellitus results from a loss of insulin-producing beta-cells in the pancreatic islets caused by an immune-mediated chronic destructive process. It is generally beli...

422. (Journal Article): Complementary therapies and diabetes

Dunning T
 
ABSTRACT: There is increasing recognition that people with diabetes use a range of complementary therapies (CT), for a number of conditions, but do not always inform their conventional healt...

423. (Journal Article): Adherence to Guidelines and its Effects on Hospitalizations with Complications of Type 2 Diabetes

Sloan FA, Bethel MA, Lee PP, Brown DS, Feinglos MN
 
ABSTRACT: OBJECTIVES: To study the discrepancy between actual and recommended rates of use among several measures of screening for complications of diabetes in a national longitudinal sample...

424. (Journal Article): Association of Postprandial Hyperglycemia with in Vitro LDL Oxidation in Non-Smoking Patients with Type 1 Diabetes – a Cross-Sectional Study

de Castro SH, Castro-Faria-Neto HC, Gomes MB
 
ABSTRACT: BACKGROUND: Cardiovascular disease is the main cause of death in patients with type 1 diabetes. Since oxidized low density lipoprotein (LDL) is considered to be a critical factor i...

425. (Journal Article): NFkappaB1 (p50)-deficient mice are not susceptible to multiple low-dose streptozotocin-induced diabetes.

Mabley JG, Hasko G, Liaudet L, Soriano F, Southan GJ, Salzman AL, Szabo C
 
ABSTRACT: Insulin-dependent diabetes mellitus (IDDM) is a disease characterized by the autoimmune destruction of the pancreatic beta-cells, which requires the expression of a number of immun...

426. (Journal Article): NFkappaB polymorphisms and susceptibility to type 1 diabetes.

Hegazy DM, O'Reilly DA, Yang BM, Hodgkinson AD, Millward BA, Demaine AG
 
ABSTRACT: Nuclear factor kappa B (NFkappaB) is an important transcription factor that is involved in the response to oxidative stress and inflammation. Recent studies suggest that it may be ...

427. (Journal Article): A sudden decline in active membrane-bound TGF-beta impairs both T regulatory cell function and protection against autoimmune diabetes.

Gregg RK, Jain R, Schoenleber SJ, Divekar R, Bell JJ, Lee HH, Yu P, Zaghouani H
 
ABSTRACT: Autoimmunity presumably manifests as a consequence of a shortfall in the maintenance of peripheral tolerance by CD4(+)CD25(+) T regulatory cells (Tregs). However, the mechanism und...

428. (Journal Article): Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

Evans JL, Goldfine ID, Maddux BA, Grodsky GM
 
ABSTRACT: In both type 1 and type 2 diabetes, diabetic complications in target organs arise from chronic elevations of glucose. The pathogenic effect of high glucose, possibly in concert wit...

429. (Journal Article): The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES
 
ABSTRACT: Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in mu...

430. (Journal Article): Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI
 
ABSTRACT: Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifact...