151. (Journal Article): Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.

Contreras JL, Wu H, Smyth CA, Eckstein CP, Young CJ, Seki T, Bilbao G, Curiel DT, Eckhoff DE
 
ABSTRACT: BACKGROUND: New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The abilit...

152. (Journal Article): Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

Klein D, Ribeiro MM, Mendoza V, Jayaraman S, Kenyon NS, Pileggi A, Molano RD, Inverardi L, Ricordi C, Pastori RL
 
ABSTRACT: Viability of isolated islets is one of the main obstacles limiting islet transplantation success. It has been reported that overexpression of Bcl-2/Bcl-XL proteins enhances islet v...

153. (Journal Article): Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

DeFronzo RA
 
ABSTRACT: n.a.

154. (Journal Article): A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.

Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C
 
ABSTRACT: Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of beta cells in the islets of Langerhans. Low expression of antioxidants a...

155. (Journal Article): Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma-mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B
 
ABSTRACT: Insulin-dependent diabetes mellitus is an autoimmune disease in which pancreatic islet beta cells are destroyed by a combination of immunological and inflammatory mechanisms. In pa...

156. (Journal Article): Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.

Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX
 
ABSTRACT: A number of studies have suggested B7-H1, a B7 family member, inhibits T cell responses. Therefore, its expression on nonlymphoid tissues has been proposed to prevent T cell-mediat...

157. (Journal Article): A second pathway for regeneration of adult exocrine and endocrine pancreas.

Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE
 
ABSTRACT: Substantial regeneration of both the endocrine and exocrine pancreas occurs after a 90% partial pancreatectomy in the young adult rat. We have reported previously that replication ...

158. (Journal Article): Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes.

Guz Y, Nasir I, Teitelman G
 
ABSTRACT: We previously reported that new beta cells differentiated in pancreatic islets of mice in which diabetes was produced by injection of a high dose of the beta cell toxin streptozoto...

159. (Journal Article): In vitro cultivation of human islets from expanded ductal tissue.

Bonner-Weir S, Taneja M, Weir GC, Tatarkiewics K, Song KH, Sharma A, O'Neil JJ
 
ABSTRACT: A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an inadequate supply of insulin-producing tissue. This need for transplantable human islets h...

160. (Journal Article): Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter.

Lechner A, Leech CA, Abraham EJ, Nolan AL, Habener JF
 
ABSTRACT: The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet ...