51. (Journal Article): Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.

Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y.
 
ABSTRACT: Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to ...

52. (Journal Article): New developments in the incretin concept.

Creutzfeldt W, Ebert R
 
ABSTRACT: Experimental and clinical work over the last 6 years has confirmed and broadened, but also challenged, the incretin concept. The nervous component of the entero-insular axis is sti...

53. (Journal Article): Sedentary death syndrome

Lees SJ, Booth FW
 
ABSTRACT: Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physi...

54. (Journal Article): Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children

Boutin P, Gresh L, Cisse A, Hara M, Bell G, Babu S, Eisenbarth G, Froguel P
 
ABSTRACT: Article has no abstract.

55. (Journal Article): Insulin-dependent diabetes mellitus as an autoimmune disease.

Bach JF
 
ABSTRACT: IDDM is unquestionably an autoimmune disease, as reflected by the presence of beta-cell-reactive autoantibodies and T cells, T cell-mediated transfer of the disease in nondiabetic ...

56. (Journal Article): {alpha}L integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium

Huang M, Matthews K, Siahaan TJ, Kevil CG
 
ABSTRACT: Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet beta cell destruction. We examined integrin requirements and specific inhibition of integrin...

57. (Journal Article): Bcl-2 protection of islet allografts is unmasked by costimulation blockade

Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, Lew AM
 
ABSTRACT: One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and ...

58. (Journal Article): Vitamin D target proteins: function and regulation.

Christakos S, Barletta F, Huening M, Dhawan P, Liu Y, Porta A, Peng X
 
ABSTRACT: Recent findings have indicated that calbindin-D(28k), the first known target of vitamin D action, is present in osteoblasts and protects against TNF and glucocorticoid induced apop...

59. (Journal Article): No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose.

Vilsboll T, Krarup T, Madsbad S, Holst JJ
 
ABSTRACT: AIMS: It has previously been shown that intravenous and subcutaneous administration of glucagon-like peptide (GLP)-1 concomitant with intravenous glucose results in reactive hypogl...

60. (Journal Article): Eighty years after insulin: parallels with modern islet transplantation.

Shapiro J
 
ABSTRACT: This year marks the 80th anniversary of the publication in CMAJ of the discovery of insulin by Frederick Banting and his colleagues at the University of Toronto. Some interesting h...