451. (Journal Article): Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles

Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI
 
ABSTRACT: Variation at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes, including type 1 diabetes, polycystic ovary ...

452. (Journal Article): Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes.

Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI
 
ABSTRACT: Type 1 diabetes is a T-cell-mediated disease that is associated with loss of immunological tolerance to self-antigens. The mechanisms involved in maintenance of peripheral toleranc...

453. (Journal Article): Reduced insulinotropic effect of gastric inhibitory polypeptide in first-degree relatives of patients with type 2 diabetes.

Meier JJ, Hucking K, Holst JJ, Deacon CF, Schmiegel WH, Nauck MA
 
ABSTRACT: In patients with type 2 diabetes, gastric inhibitory polypeptide (GIP) has lost much of its insulinotropic activity. Whether this is similar in first-degree relatives of patients w...

454. (Journal Article): Type 2 Diabetes Mellitus and its Complications: From the Molecular Biology to the Clinical Practice

Malecki MT
 
ABSTRACT: Introduction: Probably the most urgent problem in the field of diabetology, and one of the most important in XXI. century medicine, is an epidemic of type 2 diabetes mellitus. ...

455. (Journal Article): Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy

Moczulski DK, Grzeszczak W, Gawlik B
 
ABSTRACT: OBJECTIVE: In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associ...

456. (Journal Article): Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC
 
ABSTRACT: Type 2 diabetes is characterized by impaired insulin secretion. Some but not all studies suggest that a decrease in beta-cell mass contributes to this. We examined pancreatic tissu...

457. (Journal Article): Excess costs of medical care for patients with diabetes in a managed care population

Selby JV, Ray GT, Zhang D, Colby CJ
 
ABSTRACT: OBJECTIVE: To estimate the excess costs of medical care for patients with diabetes in a managed care population and to determine the proportion of costs spent on treating the compl...

458. (Journal Article): Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.

Wild S, Roglic G, Green A, Sicree R, King H
 
ABSTRACT: OBJECTIVE: The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030. RESEARCH DESIGN AND METHODS...

459. (Journal Article): Early glycemic control, age at onset, and development of microvascular complications in childhood-onset type 1 diabetes: a population-based study in northern Sweden.

Svensson M, Eriksson JW, Dahlquist G
 
ABSTRACT: OBJECTIVE: The aim of this work was to study the impact of glycemic control (HbA(1c)) early in disease and age at onset on the occurrence of incipient diabetic nephropathy (MA) and...

460. (Journal Article): Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

King H, Aubert RE, Herman WH
 
ABSTRACT: OBJECTIVE: To estimate the prevalence of diabetes and the number of people with diabetes who are > or =20 years of age in all countries of the world for three points in time, i....