251. (Journal Article): Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.

Rabinovitch A, Suarez-Pinzon WL
 
ABSTRACT: Insulin-dependent diabetes mellitus (IDDM) is a disease that results from autoimmune destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. The aut...

252. (Question/Problem): What is MODY: What is MODY

253. (Information): Operating Guidelines and Conditions of Use for Editors of the Diabetes Open Directory - DOD

Info SBDR
 
ABSTRACT: n.a.

254. (Journal Article): Autoimmune Diabetes: Ongoing Development of Immunological Intervention Strategies Targeted Directly Against Autoreactive T Cells

Sia C
 
ABSTRACT: It is well known that autoimmunity associated with the onset of insulin-dependent diabetes mellitus (IDDM) involves the generation of autoreactive T and B cells. The findings that ...

255. (Journal Article): A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity

Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh B
 
ABSTRACT: We have established a novel CD4 and CD8 double-positive CD25+ T regulatory (Treg) clone, MT-5B, from lymph nodes of type 1 diabetes prone non-obese diabetic (NOD) mice immunized wi...

256. (Journal Article): ENPP1 K121Q Polymorphism is not Related to Type 2 Diabetes Mellitus, Features of Metabolic Syndrome, and Diabetic Cardiovascular Complications in a Chinese Population

Chen MP, Chung FM, Chang DM, Tsai JC, Huang HF, Shin SJ, Lee YJ
 
ABSTRACT: BACKGROUND: Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) is known to influence insulin sensitivity by inhibiting insulin receptor signaling. A DNA polymorphism i...

257. (Journal Article): Gene regulatory factors in pancreatic development.

Jensen J
 
ABSTRACT: The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin-producing beta-cells normall...

258. (Journal Article): Differential role of programmed death-1 ligand and programmed death-2 ligand in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis.

Zhu B, Guleria I, Khosroshahi A, Chitnis T, Imitola J, Azuma M, Yagita H, Sayegh MH, Khoury SJ
 
ABSTRACT: Programmed death-1 (PD-1) is a negative costimulatory molecule, and blocking the interaction of PD-1 with its ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC), enhances autoimmune disease ...

259. (Journal Article): Antidiabetic, antioxidant and antihyperlipidemic status of heliotropium zeylanicum extract on streptozotocin-induced diabetes in rats

Murugesh K, Yeligar V, Dash DK, Sengupta P, Maiti BC, Maity TK.
 
ABSTRACT: The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects ...

260. (Journal Article): Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes

Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S.
 
ABSTRACT: 1. The effect of diabetes mellitus on lipid metabolism is well established. The association of hyperglycaemia with an alteration of lipid parameters presents a major risk for cardi...