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61. (Journal Article): Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Miyawaki K, Yamada Y, Yano H, Niwa H, Ban N, Ihara Y, Kubota A, Fujimoto S, Kajikawa M, Kuroe A, Tsuda K, Hashimoto H, Yamashita T, Jomori T, Tashiro F, Miyazaki J, Seino Y. ABSTRACT:
Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP) receptor gene (GIPR) were generated to determine the role of GIP as a mediator of signals from the gut to ...
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Diabetes OD
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Diabetes Pathogenesi...
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T2DM
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Glucose Intolerance
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GIP
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Entero-Insular Axis
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Journal Article
submitted: Sep 01, 2005 |
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62. (Journal Article): New developments in the incretin concept.
Creutzfeldt W, Ebert R ABSTRACT:
Experimental and clinical work over the last 6 years has confirmed and broadened, but also challenged, the incretin concept. The nervous component of the entero-insular axis is sti...
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Diabetes OD
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Diabetes Pathogenesi...
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T2DM
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Insulin Secretion
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Incretin Hormones
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GIP
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Enteroinsular Axis
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Journal Article
submitted: Nov 24, 2005 |
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63. (Journal Article): Sedentary death syndrome
Lees SJ, Booth FW ABSTRACT:
Sedentary death syndrome (SeDS) is a major public health burden due to its causing multiple chronic diseases and millions of premature deaths each year. Despite the impact of physi...
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Diabetes OD
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Diabetes Pathogenesi...
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T2DM
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Risk Factors and Sus...
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Journal Article
submitted: Aug 22, 2004 |
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64. (Journal Article): Missense mutation Gly574Ser in the transcription factor HNF-1alpha is a marker of atypical diabetes mellitus in African-American children
Boutin P, Gresh L, Cisse A, Hara M, Bell G, Babu S, Eisenbarth G, Froguel P ABSTRACT:
Article has no abstract.
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Diabetes OD
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Diabetes Pathogenesi...
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MODY
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Genetics
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Mutations
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MODY3
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HNF-1α
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Journal Article
submitted: Dec 19, 2004 |
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65. (Journal Article): Insulin-dependent diabetes mellitus as an autoimmune disease.
Bach JF ABSTRACT:
IDDM is unquestionably an autoimmune disease, as reflected by the presence of beta-cell-reactive autoantibodies and T cells, T cell-mediated transfer of the disease in nondiabetic ...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Re-establishing Tole...
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Modifying Immunity
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Recent Onset
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Systemic Interventio...
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T cells
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Anti-CD3 Therapy
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Journal Article
submitted: Dec 04, 2005 |
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66. (Journal Article): {alpha}L integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium
Huang M, Matthews K, Siahaan TJ, Kevil CG ABSTRACT:
Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet beta cell destruction. We examined integrin requirements and specific inhibition of integrin...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Re-establishing Tole...
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Modifying Immunity
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Past Onset
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Site-Specific Interv...
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Journal Article
submitted: Aug 22, 2004 |
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67. (Journal Article): Bcl-2 protection of islet allografts is unmasked by costimulation blockade
Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, Lew AM ABSTRACT:
One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and ...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Immunosuppression
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Journal Article
submitted: Aug 25, 2004 |
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68. (Journal Article): Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma-mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.
Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B ABSTRACT:
Insulin-dependent diabetes mellitus is an autoimmune disease in which pancreatic islet beta cells are destroyed by a combination of immunological and inflammatory mechanisms. In pa...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Beta-Cell Protection
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Cytokine suppression
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Inhibition of NF-kB ...
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Journal Article
submitted: Jan 07, 2006 |
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69. (Journal Article): A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.
Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C ABSTRACT:
Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of beta cells in the islets of Langerhans. Low expression of antioxidants a...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Beta-Cell Protection
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Cytokine suppression
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Inhibition of NF-kB ...
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Journal Article
submitted: Jan 07, 2006 |
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70. (Journal Article): Vitamin D target proteins: function and regulation.
Christakos S, Barletta F, Huening M, Dhawan P, Liu Y, Porta A, Peng X ABSTRACT:
Recent findings have indicated that calbindin-D(28k), the first known target of vitamin D action, is present in osteoblasts and protects against TNF and glucocorticoid induced apop...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Beta-Cell Protection
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Calcium-Binding Prot...
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Journal Article
submitted: May 27, 2005 |
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