401. (Journal Article): Islet Redox Stress: The Manifold Toxicities of Insulin Resistance, Metabolic Syndrome and Amylin Derived Islet Amyloid in Type 2 Diabetes Mellitus

Hayden MR, Tyagi SC
 
ABSTRACT: CONTEXT: Redox stress, reactive oxygen species, reactive nitrogen species, and oxygen free radicals ('toxic oxygen') are increasingly being reported as important cellular signaling...

402. (Journal Article): The Course of Genetically Determined Chronic Pancreatitis

Keim V, Witt H, Bauer N, Bodeker H, Rosendahl J, Teich N, Mossner J
 
ABSTRACT: CONTEXT: The clinical course of chronic pancreatitis in patients with mutations of cationic trypsinogen and the trypsin inhibitor SPINK1 has not yet been characterized. SETTING: Ca...

403. (Journal Article): Type 2 Diabetes Mellitus as a Conformational Disease

Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR
 
ABSTRACT: Conformational diseases are conditions that arise from the dysfunctional aggregation of proteins in non-native conformations. Type 2 diabetes mellitus can be defined as a conformat...

404. (Journal Article): The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice.

Ansari MJ, Salama AD, Chitnis T, Smith RN, Yagita H, Akiba H, Yamazaki T, Azuma M, Iwai H, Khoury SJ
 
ABSTRACT: Programmed death-1 (PD-1) receptor, an inhibitory costimulatory molecule found on activated T cells, has been demonstrated to play a role in the regulation of immune responses and ...

405. (Journal Article): Mucosal Tolerance to Prevent Type 1 Diabetes: Can the Outcome Be Improved in Humans?

Hanninen A, Harrison LC
 
ABSTRACT: The results of trials in which autoantigens have been fed to individuals affected by autoimmune diseases - multiple sclerosis, rheumatoid arthritis and type 1 diabetes - have been ...

406. (Journal Article): Eat less, walk more. Enjoyable eating for type 2 diabetes.

Phillips P, Carapetis M
 
ABSTRACT: BACKGROUND: Lifestyle management is the basis of diabetes treatment. In most cases, healthy eating, activity and weight loss can result in significant improvements in blood glucose...

407. (Journal Article): Can the Glycemic Index (GI) be Used as a Tool in the Prevention and Management of Type 2 Diabetes?

Hermansen ML, Eriksen NM, Mortensen LS, Holm L, Hermansen K
 
ABSTRACT: The large increase in type 2 diabetes (T2DM), the considerable lifetime risk of diabetes and the loss of lifetime call for concerted action to prevent T2DM and its complications. S...

408. (Journal Article): Can the Glycemic Index (GI) be Used as a Tool in the Prevention and Management of Type 2 Diabetes?

Hermansen ML, Eriksen NM, Mortensen LS, Holm L, Hermansen K
 
ABSTRACT: The large increase in type 2 diabetes (T2DM), the considerable lifetime risk of diabetes and the loss of lifetime call for concerted action to prevent T2DM and its complications. S...

409. (Journal Article): Prevalence of Type 2 Diabetic Patients Within the Targets of Care Guidelines in Daily Clinical Practice: A Multi-Center Study in Brazil

Gomes MB, Gianella D, Faria M, Tambascia M, Fonseca RM, Rea R, Macedo G, Filho JM, Schmid H, Bittencourt AV, Cavalcanti S, Rassi N, Pedrosa H, Dib SA
 
ABSTRACT: Major clinical studies have shown that the targets for blood glucose, lipid profile and blood pressure in type 2 diabetic patients are difficult to maintain in clinical practice. H...

410. (Journal Article): Remission in models of type 1 diabetes by gene therapy using a single chain insulin-analogue.

Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW
 
ABSTRACT: A cure for diabetes has long been sought using several different approaches, including islet transplantation, regeneration of beta cells and insulin gene therapy. However, permanen...