371. (Journal Article): A Case of Acquired Generalized Lipodystrophy with Cerebellar Degeneration and Type 2 Diabetes Mellitus

Chao PJ, Tsai JCR, Chang DM, Shin SJ, Lee YJ
 
ABSTRACT: Acquired generalized lipodystrophy (AGL) is a rare disorder of adipose tissue characterized by loss of fat from large regions of the body, occurring after birth. Its etiology remai...

372. (Journal Article): Insulin production by human embyronic stem cells.

Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL
 
ABSTRACT: Type 1 diabetes generally results from autoimmune destruction of pancreatic islet beta-cells, with consequent absolute insulin deficiency and complete dependence on exogenous insul...

373. (Journal Article): Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta-cell identity and function.

Mckinnon CM, Docherty K
 
ABSTRACT: Pancreatic duodenal homeobox -1 is a transcription factor that is expressed in beta and delta cells of the islets of Langerhans and in dispersed endocrine cells of the duodenum. It...

374. (Journal Article): Imbalance in Th Cell Polarization and its Relevance in Type 1 Diabetes Mellitus

Sia C
 
ABSTRACT: Functional polarization of T helper (Th) subsets of lymphocytes has been implicated in promoting or conferring risk to Type 1 diabetes mellitus (T1DM) development in human and diab...

375. (Journal Article): XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes

Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF
 
ABSTRACT: The Edmonton Protocol for treatment of type 1 diabetes requires islets from two or more donors to achieve euglycemia in a single recipient, primarily because soon after portal infu...

376. (Journal Article): NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.

Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L
 
ABSTRACT: To explore induced islet neogenesis in the liver as a strategy for the treatment of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the pancreatic duodenal homeobox...

377. (Journal Article): Tumor necrosis factor-alpha regulation of CD4+CD25+ T cell levels in NOD mice.

Wu AJ, Hua H, Munson SH, McDevitt HO
 
ABSTRACT: The mechanism by which tumor necrosis factor-alpha (TNF) differentially modulates type I diabetes mellitus in the nonobese diabetic (NOD) mouse is not well understood. CD4+CD25+ T ...

378. (Journal Article): A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription fac-tors and is associated with susceptibility to type I diabetes mel-litus.

Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D
 
ABSTRACT: Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance protein stability and act...

379. (Journal Article): T-cell education in autoimmune diabetes: teachers and students.

Rosmalen JG, van Ewijk W, Leenen PJ
 
ABSTRACT: Type 1 diabetes mellitus is a classical example of a T-cell-mediated autoimmune disease. Several aberrations in immune regulation have been described in both human diabetes patient...

380. (Journal Article): Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.

Daniel D, Gill RG, Schloot N, Wegmann D
 
ABSTRACT: T cells are known to play an important role in beta cell destruction in the nonobese diabetic (NOD) mouse model of Type I diabetes and islet-specific T cell clones have been demons...