351. (Journal Article): Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

Chatenoud L
 
ABSTRACT: Major progress has been made over the last 10 years in understanding the immune mechanisms underlying autoimmune Type I (insulin-dependent) diabetes mellitus. It seems that immunot...

352. (Journal Article): Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F
 
ABSTRACT: Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell cl...

353. (Journal Article): B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes.

Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA
 
ABSTRACT: CD28/B7 costimulation has been implicated in the induction and progression of autoimmune diseases. Experimentally induced models of autoimmunity have been shown to be prevented or ...

354. (Journal Article): Functional, molecular, and biochemical characterization of streptozotocin-induced diabetes.

Ward DT, Yau SK, Mee AP, Mawer EB, Miller CA, Garland HO, Riccardi D
 
ABSTRACT: Altered divalent cation homeostasis with bone mineral loss, hypercalciuria, and hypomagnesemia have been associated consistently with human diabetes mellitus. This study investigat...

355. (Journal Article): Beta cell apoptosis in T cell-mediated autoimmune diabetes.

Kurrer MO, Pakala SV, Hanson HL, Katz JD
 
ABSTRACT: Insulin-dependent diabetes mellitus results from T cell-mediated destruction of insulin-producing, pancreatic islet beta cells. How this destruction takes place has remained elusiv...

356. (Journal Article): The beta cell in autoimmune diabetes: many mechanisms and pathways of loss.

Kay TW, Thomas HE, Harrison LC, Allison J
 
ABSTRACT: Death of pancreatic beta cells is the final step in the pathogenesis of type 1 diabetes before it becomes clinically apparent. Applying recent basic research about how cells die to...

357. (Journal Article): TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L
 
ABSTRACT: CD3-specific antibodies have the unique capacity to restore self-tolerance in established autoimmunity. They induce long-term remission of overt diabetes in nonobese diabetic (NOD)...

358. (Journal Article): cFLIP protein prevents tumor necrosis factor-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells.

Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B
 
ABSTRACT: Type 1 diabetes is characterized by the infiltration of activated leukocytes within the pancreatic islets, leading to beta-cell dysfunction and destruction. The exact role played b...

359. (Journal Article): Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study.

Zander M, Madsbad S, Madsen JL, Holst JJ
 
ABSTRACT: BACKGROUND: Glucagon-like peptide 1 (GLP-1) has been proposed as a treatment for type 2 diabetes. We have investigated the long-term effects of continuous administration of this pe...

360. (Journal Article): Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Hui H, Khoury N, Zhao X, Balkir L, D’Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R
 
ABSTRACT: Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little...