291. (Journal Article): NOD mice are defective in proteasome production and activation of NF-kappaB.

Hayashi T, Faustman D
 
ABSTRACT: The nonobese diabetic (NOD) mouse is an animal model of human type I diabetes with a strong genetic component that maps to the major histocompatibility complex (MHC) of the genome....

292. (Journal Article): CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes.

Tarbell KV, Yamazaki S, Olson K, Toy P, Steinman RM
 
ABSTRACT: In the nonobese diabetic (NOD) mouse model of type 1 diabetes, the immune system recognizes many autoantigens expressed in pancreatic islet beta cells. To silence autoimmunity, we ...

293. (Journal Article): Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.

Hori Y, Rulifson IC, Tsai BC, Heit JJ, Cahoy JD, Kim SK
 
ABSTRACT: The use of embryonic stem cells for cell-replacement therapy in diseases like diabetes mellitus requires methods to control the development of multipotent cells. We report that tre...

294. (Journal Article): Reversal of insulin-dependent diabetes using islet cells generated in vitro from pancreatic stem cells.

Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG
 
ABSTRACT: Ductal structures of the adult pancreas contain stem cells that differentiate into islets of Langerhans. Here, we grew pancreatic ductal epithelial cells isolated from prediabetic ...

295. (Journal Article): Histologic differentiation of human fetal pancreatic explants transplanted into nude mice.

Tuch BE, Ng AB, Jones A, Turtle JR
 
ABSTRACT: The transplantation of human fetal pancreas has been suggested as a means of treatment of insulin-dependent diabetes in man. We have obtained human fetal pancreata during the secon...

296. (Journal Article): Predisposing genetic factors for diabetic polyneuropathy in patients with type 1 diabetes: a population-based case-control study.

Strokov IA, Bursa TR, Drepa OI, Zotova EV, Nosikov VV, Ametov AS
 
ABSTRACT: Oxidative stress plays a key role in the development of microvascular complications of diabetes mellitus (DM). Antioxidant enzymes protect against the rapid onset of diabetic polyn...

297. (Journal Article): Type 1 Diabetes and NKT Cells: A Report on the 3rd International Workshop on NKT Cells and CD1-Mediated Antigen Presentation, September 2004, Heron Island, QLD, Australia

Fletcher JM, Jordan MA, Baxter AG
 
ABSTRACT: NKT cells play a major role in regulating the vigor and character of a broad range of immune responses. Defects in NKT cell numbers and function have been associated with type 1 di...

298. (Journal Article): Approaches Towards Endogenous Pancreatic Regeneration

Banerjee M, Kanitkar M, Bhonde RR
 
ABSTRACT: The phenomenon of pancreatic regeneration in mammals has been well documented. It has been shown that pancreatic tissue is able to regenerate in several species of mammal after sur...

299. (Journal Article): A novel mechanism of regulatory T cell-mediated down-regulation of autoimmunity

Qin HY, Mukherjee R, Lee-Chan E, Ewen C, Bleackley RC, Singh B
 
ABSTRACT: We have established a novel CD4 and CD8 double-positive CD25+ T regulatory (Treg) clone, MT-5B, from lymph nodes of type 1 diabetes prone non-obese diabetic (NOD) mice immunized wi...

300. (Journal Article): Gene regulatory factors in pancreatic development.

Jensen J
 
ABSTRACT: The intensity of research on pancreatic development has increased markedly in the past 5 years, primarily for two reasons: we now know that the insulin-producing beta-cells normall...