51. (Journal Article): {alpha}L integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium

Huang M, Matthews K, Siahaan TJ, Kevil CG
 
ABSTRACT: Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet beta cell destruction. We examined integrin requirements and specific inhibition of integrin...

52. (Journal Article): Bcl-2 protection of islet allografts is unmasked by costimulation blockade

Sutherland RM, Allison J, Thomas HE, Brady JL, Kay TW, Lew AM
 
ABSTRACT: One major limitation in pancreatic islet transplantation is availability of donor tissue. Donor shortage is exacerbated by islet apoptosis from the stresses of islet isolation and ...

53. (Journal Article): Dominant negative MyD88 proteins inhibit interleukin-1beta /interferon-gamma-mediated induction of nuclear factor kappa B-dependent nitrite production and apoptosis in beta cells.

Dupraz P, Cottet S, Hamburger F, Dolci W, Felley-Bosco E, Thorens B
 
ABSTRACT: Insulin-dependent diabetes mellitus is an autoimmune disease in which pancreatic islet beta cells are destroyed by a combination of immunological and inflammatory mechanisms. In pa...

54. (Journal Article): A20 inhibits cytokine-induced apoptosis and nuclear factor kappaB-dependent gene activation in islets.

Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C
 
ABSTRACT: Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease resulting from apoptotic destruction of beta cells in the islets of Langerhans. Low expression of antioxidants a...

55. (Journal Article): Vitamin D target proteins: function and regulation.

Christakos S, Barletta F, Huening M, Dhawan P, Liu Y, Porta A, Peng X
 
ABSTRACT: Recent findings have indicated that calbindin-D(28k), the first known target of vitamin D action, is present in osteoblasts and protects against TNF and glucocorticoid induced apop...

56. (Journal Article): Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

DeFronzo RA
 
ABSTRACT: n.a.

57. (Journal Article): No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose.

Vilsboll T, Krarup T, Madsbad S, Holst JJ
 
ABSTRACT: AIMS: It has previously been shown that intravenous and subcutaneous administration of glucagon-like peptide (GLP)-1 concomitant with intravenous glucose results in reactive hypogl...

58. (Journal Article): Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone.

Matsuyama T, Komatsu R, Namba M, Watanabe N, Itoh H, Tarui S
 
ABSTRACT: Glucagon-like peptide-1 (GLP-1) (1-37) and the fraction derived from it, GLP-1 (7-36 amide), are peptides encoded by the preproglucagon gene and possibly co-secreted with enteroglu...

59. (Journal Article): Eighty years after insulin: parallels with modern islet transplantation.

Shapiro J
 
ABSTRACT: This year marks the 80th anniversary of the publication in CMAJ of the discovery of insulin by Frederick Banting and his colleagues at the University of Toronto. Some interesting h...

60. (Journal Article): Delivery of Bcl-XL or its BH4 domain by protein transduction inhibits apoptosis in human islets.

Klein D, Ribeiro MM, Mendoza V, Jayaraman S, Kenyon NS, Pileggi A, Molano RD, Inverardi L, Ricordi C, Pastori RL
 
ABSTRACT: Viability of isolated islets is one of the main obstacles limiting islet transplantation success. It has been reported that overexpression of Bcl-2/Bcl-XL proteins enhances islet v...