321. (Journal Article): The Role of HLA Class I Gene Variation in Autoimmune Diabetes

Sia C, Weinem M
 
ABSTRACT: The use of DNA-based genetic typing has enabled the identification of type 1 diabetes mellitus (T1DM) susceptible and protective major histocompatibility complex (MHC) class II all...

322. (Journal Article): Replenishing Peripheral CD4+ Regulatory T Cells: A Possible Immune-Intervention Strategy in Type 1 Diabetes?

Sia C
 
ABSTRACT: Controlling the diabetogenic activity of peripheral islet antigen-specific T cells is essential to halt the progression of autoimmunity that leads to the development of type 1 diab...

323. (Journal Article): The Association of Silent Coronary Artery Disease and Metabolic Syndrome in Chinese with Type 2 Diabetes Mellitus

Tsai JCR, Chang DM, Chung FM, Wu JC, Shin SJ, Lee YJ
 
ABSTRACT: OBJECTIVES: Cardiovascular diseases account for approximately 75% of the deaths that occur in patients with diabetes. Because the clinical signs of coronary artery disease (CAD) in...

324. (Journal Article): Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen.

Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV
 
ABSTRACT: BACKGROUND: Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin thera...

325. (Journal Article): Adult human pancreatic duct and islet cells exhibit similarities in expression and differences in phosphorylation and complex formation of the homeodomain protein IPF-1.

Heimberg H, Bouwens L, Heremans Y, Van den Casteele M, Lefebvre V, Pipeleers D
 
ABSTRACT: The homeodomain transcription factor encoded by the pancreatic and duodenal homeobox gene-1 (Ipf-1) is essential for pancreatic ontogenesis. Whether Ipf-1 is also involved in the n...

326. (Journal Article): Genes Mediating Environment Interactions in Type 1 Diabetes

Biros E, Jordan MA, Baxter AG
 
ABSTRACT: The relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contrib...

327. (Journal Article): Normalization of glucose concen-trations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes.

Meier JJ, Gallwitz B, Salmen S, Goetze O, Holst JJ, Schmidt WE, Nauck MA
 
ABSTRACT: The effects of different i.v. doses of glucagon-like peptide 1 (GLP-1) on glucose homeostasis and gastric emptying were compared in patients with type 2 diabetes. Twelve patients w...

328. (Journal Article): Gastric inhibitory polypeptide: the neglected incretin revisited.

Meier JJ, Nauck MA, Schmidt WE, Gallwitz B
 
ABSTRACT: After the ingestion of fat- and glucose-rich meals, gut hormones are secreted into the circulation in order to stimulate insulin secretion. This so-called "incretin effect&quo...

329. (Journal Article): Insulin secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F
 
ABSTRACT: Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell cl...

330. (Journal Article): Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas.

Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P
 
ABSTRACT: The homeodomain protein PDX-1 is critical for pancreas development and is a key regulator of insulin gene expression. PDX-1 nullizygosity and haploinsufficiency in mice and humans ...