151. (Journal Article): {alpha}L integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium

Huang M, Matthews K, Siahaan TJ, Kevil CG
 
ABSTRACT: Insulitis is a hallmark feature of autoimmune diabetes that ultimately results in islet beta cell destruction. We examined integrin requirements and specific inhibition of integrin...

152. (Journal Article): Th17 Cells in Inflammatory Conditions

Cooke A
 
ABSTRACT: CD4+ T cells have been subdivided into different subsets, largely on the basis of the cytokines they produce. These subsets include Th1, Th2 and regulatory T cells. Recently, anoth...

153. (Journal Article): Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.

Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR
 
ABSTRACT: The calcium channel alpha2delta-1 subunit is a structural subunit important for functional calcium channel assembly. In vitro studies have shown that this subunit is the binding si...

154. (Journal Article): Low-Protein Vegetarian Diet with Alpha-Chetoanalogues Prior to Pre-emptive Pancreas-Kidney Transplantation

Piccoli GB, Motta D, Martina G, Consiglio V, Gai M, Mezza E, Maddalena E, Burdese M, Colla L, Tattoli F, Anania P, Rossetti M, Soragna G, Grassi G, Dani F, Jeantet A, Segoloni GP
 
ABSTRACT: BACKGROUND: Pre-emptive pancreas-kidney transplantation is increasingly considered the best therapy for irreversible chronic kidney disease (CKD) in type 1 diabetics. However, the ...

155. (Journal Article): Novel Insights in the Regulation of the Immune System: A Report on the FASEB Summer Research Conference on Autoimmunity, 2003

Gronski MA
 
ABSTRACT: The bi-annual FASEB autoimmunity conference organized last year by Betty Diamond and Stephen Miller brought together some 150 delegates studying various aspects of autoimmune disea...

156. (Journal Article): Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.

Subudhi SK, Zhou P, Yerian LM, Chin RK, Lo JC, Anders RA, Sun Y, Chen L, Wang Y, Alegre ML, Fu YX
 
ABSTRACT: A number of studies have suggested B7-H1, a B7 family member, inhibits T cell responses. Therefore, its expression on nonlymphoid tissues has been proposed to prevent T cell-mediat...

157. (Journal Article): A second pathway for regeneration of adult exocrine and endocrine pancreas.

Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE
 
ABSTRACT: Substantial regeneration of both the endocrine and exocrine pancreas occurs after a 90% partial pancreatectomy in the young adult rat. We have reported previously that replication ...

158. (Journal Article): Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes.

Guz Y, Nasir I, Teitelman G
 
ABSTRACT: We previously reported that new beta cells differentiated in pancreatic islets of mice in which diabetes was produced by injection of a high dose of the beta cell toxin streptozoto...

159. (Journal Article): In vitro cultivation of human islets from expanded ductal tissue.

Bonner-Weir S, Taneja M, Weir GC, Tatarkiewics K, Song KH, Sharma A, O'Neil JJ
 
ABSTRACT: A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an inadequate supply of insulin-producing tissue. This need for transplantable human islets h...

160. (Journal Article): Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter.

Lechner A, Leech CA, Abraham EJ, Nolan AL, Habener JF
 
ABSTRACT: The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet ...