91. (Journal Article): Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.

Lee JH, Cribbs LL, Perez-Reyes E
 
ABSTRACT: Cloning has led to the discovery of more ion channels than predicted by functional studies, yet there remain channels that have not been cloned. We report the cloning of a novel pr...

92. (Journal Article): Molecular studies of the asymmetric pore structure of the human cardiac voltage-dependent Ca2+ channel.

Klockner U, Mikala G, Schwartz A, Varadi G
 
ABSTRACT: Proton transfer to calcium channels results in rapid fluctuations between two non-zero conductance levels when the current is carried by monovalent cations. A combination of site-d...

93. (Journal Article): Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A
 
ABSTRACT: In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the io...

94. (Journal Article): Architecture of Ca(2+) channel pore-lining segments revealed by covalent modification of substituted cysteines.

Koch SE, Bodi I, Schwartz A, Varadi G
 
ABSTRACT: The cysteine accessibility method was used to explore calcium channel pore topology. Cysteine mutations were introduced into the SS1-SS2 segments of Motifs I-IV of the human cardia...

95. (Journal Article): Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH
 
ABSTRACT: 1. This study examined the action of gabapentin (gabapentin,1-(aminomethyl) cyclohexane acetic acid (Neurontin) on voltage-gated calcium (Ca(2+)) channel influx recorded in culture...

96. (Journal Article): Auxiliary subunits: essential components of the voltage-gated calcium channel complex

Arikkath J, Campbell KP
 
ABSTRACT: Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the chann...

97. (Journal Article): Insulin secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F
 
ABSTRACT: Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell cl...

98. (Journal Article): Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner.

De Lisle RC, Logsdon CD
 
ABSTRACT: In the current study two monoclonal antibodies (mAb) were used to investigate the expression of adult acinar and duct cell-specific antigens and their relationship with cell growth...

99. (Journal Article): Prevalence of Type 2 Diabetic Patients Within the Targets of Care Guidelines in Daily Clinical Practice: A Multi-Center Study in Brazil

Gomes MB, Gianella D, Faria M, Tambascia M, Fonseca RM, Rea R, Macedo G, Filho JM, Schmid H, Bittencourt AV, Cavalcanti S, Rassi N, Pedrosa H, Dib SA
 
ABSTRACT: Major clinical studies have shown that the targets for blood glucose, lipid profile and blood pressure in type 2 diabetic patients are difficult to maintain in clinical practice. H...

100. (Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
 
ABSTRACT: Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...