61. (Journal Article): Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells.

Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH
 
ABSTRACT: The functional properties of dendritic cells (DCs) are strictly dependent on their maturational state. To analyze the influence of the maturational state of DCs on priming and diff...

62. (Journal Article): Calmodulin-induced early-onset diabetes in transgenic mice.

Epstein PN, Overbeek PA, Means AR
 
ABSTRACT: Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of ...

63. (Journal Article): Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases.

McGuirk P, Mills KH
 
ABSTRACT: Current dogma suggests that immunity to infection is controlled by distinct type 1 (Th1) and type 2 (Th2) subpopulations of T cells discriminated on the basis of cytokine secretion...

64. (Journal Article): Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man.

Hvidberg A, Nielsen MT, Hilsted J, 0rskov C, Holst JJ
 
ABSTRACT: The newly discovered intestinal hormone, glucagon-like peptide-1 (GLP-1) (proglucagon 78-107amide), stimulates insulin secretion and inhibits glucagon secretion in man and may ther...

65. (Journal Article): Control of early development of the pancreas in rodents and humans: implications of signals from the mesenchyme.

Scharfmann R
 
ABSTRACT: During the last few years, progress has been made in the control of pancreatic development. Many transcription factors have been described in the pancreas and a genetic approach ha...

66. (Journal Article): Insulin production by human embryonic stem cells.

Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M
 
ABSTRACT: Type 1 diabetes generally results from autoimmune destruction of pancreatic islet beta-cells, with consequent absolute insulin deficiency and complete dependence on exogenous insul...

67. (Journal Article): Accelerated telomere shortening and senescence in human pancreatic islet cells stimulated to divide in vitro.

Halvorsen TL, Beattie GM, Lopez AD, Hayek A, Levine F
 
ABSTRACT: Widespread application of beta-cell replacement strategies for diabetes is dependent upon the availability of an unlimited supply of cells exhibiting appropriate glucose-responsive...

68. (Journal Article): Autoimmune Diabetes: Ongoing Development of Immunological Intervention Strategies Targeted Directly Against Autoreactive T Cells

Sia C
 
ABSTRACT: It is well known that autoimmunity associated with the onset of insulin-dependent diabetes mellitus (IDDM) involves the generation of autoreactive T and B cells. The findings that ...

69. (Journal Article): Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes

Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S.
 
ABSTRACT: 1. The effect of diabetes mellitus on lipid metabolism is well established. The association of hyperglycaemia with an alteration of lipid parameters presents a major risk for cardi...

70. (Journal Article): Infection and autoimmunity: are we winning the war, only to lose the peace?

Cooke A, Zaccone P, Raine T, Phillips JM, Dunne DW
 
ABSTRACT: Not available