41. (Journal Article): Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit.

Rottbauer W, Baker K, Wo ZG, Mohideen MA, Cantiello HF, Fishman MC
 
ABSTRACT: The heart must function from the moment of its embryonic assembly, but the molecular underpinnings of the first heart beat are not known, nor whether function determines form at th...

42. (Journal Article): Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site.

Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA
 
ABSTRACT: Ca(v)2.1 and Ca(v)2.2 channels conduct P/Q-type and N-type Ca(2+) currents that initiate neurotransmission and bind SNARE proteins through a synaptic protein interaction (synprint)...

43. (Journal Article): Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.

Lee JH, Cribbs LL, Perez-Reyes E
 
ABSTRACT: Cloning has led to the discovery of more ion channels than predicted by functional studies, yet there remain channels that have not been cloned. We report the cloning of a novel pr...

44. (Journal Article): Molecular studies of the asymmetric pore structure of the human cardiac voltage-dependent Ca2+ channel.

Klockner U, Mikala G, Schwartz A, Varadi G
 
ABSTRACT: Proton transfer to calcium channels results in rapid fluctuations between two non-zero conductance levels when the current is carried by monovalent cations. A combination of site-d...

45. (Journal Article): Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A
 
ABSTRACT: In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the io...

46. (Journal Article): Architecture of Ca(2+) channel pore-lining segments revealed by covalent modification of substituted cysteines.

Koch SE, Bodi I, Schwartz A, Varadi G
 
ABSTRACT: The cysteine accessibility method was used to explore calcium channel pore topology. Cysteine mutations were introduced into the SS1-SS2 segments of Motifs I-IV of the human cardia...

47. (Journal Article): Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH
 
ABSTRACT: 1. This study examined the action of gabapentin (gabapentin,1-(aminomethyl) cyclohexane acetic acid (Neurontin) on voltage-gated calcium (Ca(2+)) channel influx recorded in culture...

48. (Journal Article): Auxiliary subunits: essential components of the voltage-gated calcium channel complex

Arikkath J, Campbell KP
 
ABSTRACT: Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the chann...

49. (Journal Article): Insulin secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice.

Soria B, Roche E, Berna G, Leon-Quinto T, Reig JA, Martin F
 
ABSTRACT: Embryonic stem (ES) cells display the ability to differentiate in vitro into a variety of cell lineages. Using a cell-trapping system, we have obtained an insulin-secreting cell cl...

50. (Journal Article): Pancreatic acinar cells in culture: expression of acinar and ductal antigens in a growth-related manner.

De Lisle RC, Logsdon CD
 
ABSTRACT: In the current study two monoclonal antibodies (mAb) were used to investigate the expression of adult acinar and duct cell-specific antigens and their relationship with cell growth...