11. (Journal Article): The Diterpene Glycoside, Rebaudioside A, Does not Improve Glycemic Control or Affect Blood Pressure After Eight Weeks Treatment in the Goto-Kakizaki Rat

Dyrskog SEU, Jeppesen PB, Chen J, Christensen LP, Hermansen K
 
ABSTRACT: The plant, Stevia rebaudiana Bertoni (SrB), has been used for the treatment of diabetes in traditional medicine. Previously, we have demonstrated that long-term administration of t...

12. (Journal Article): Low-Protein Vegetarian Diet with Alpha-Chetoanalogues Prior to Pre-emptive Pancreas-Kidney Transplantation

Piccoli GB, Motta D, Martina G, Consiglio V, Gai M, Mezza E, Maddalena E, Burdese M, Colla L, Tattoli F, Anania P, Rossetti M, Soragna G, Grassi G, Dani F, Jeantet A, Segoloni GP
 
ABSTRACT: BACKGROUND: Pre-emptive pancreas-kidney transplantation is increasingly considered the best therapy for irreversible chronic kidney disease (CKD) in type 1 diabetics. However, the ...

13. (Journal Article): Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.

Ellis SB, Williams ME, Ways NR, Brenner R, Sharp AH, Leung AT, Campbell KP, McKenna E, Koch WJ, Hui A
 
ABSTRACT: Complementary DNAs were isolated and used to deduce the primary structures of the alpha 1 and alpha 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel f...

14. (Journal Article): Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit.

Rottbauer W, Baker K, Wo ZG, Mohideen MA, Cantiello HF, Fishman MC
 
ABSTRACT: The heart must function from the moment of its embryonic assembly, but the molecular underpinnings of the first heart beat are not known, nor whether function determines form at th...

15. (Journal Article): Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site.

Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA
 
ABSTRACT: Ca(v)2.1 and Ca(v)2.2 channels conduct P/Q-type and N-type Ca(2+) currents that initiate neurotransmission and bind SNARE proteins through a synaptic protein interaction (synprint)...

16. (Journal Article): Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.

Lee JH, Cribbs LL, Perez-Reyes E
 
ABSTRACT: Cloning has led to the discovery of more ion channels than predicted by functional studies, yet there remain channels that have not been cloned. We report the cloning of a novel pr...

17. (Journal Article): Molecular studies of the asymmetric pore structure of the human cardiac voltage-dependent Ca2+ channel.

Klockner U, Mikala G, Schwartz A, Varadi G
 
ABSTRACT: Proton transfer to calcium channels results in rapid fluctuations between two non-zero conductance levels when the current is carried by monovalent cations. A combination of site-d...

18. (Journal Article): Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.

Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A
 
ABSTRACT: In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the io...

19. (Journal Article): Architecture of Ca(2+) channel pore-lining segments revealed by covalent modification of substituted cysteines.

Koch SE, Bodi I, Schwartz A, Varadi G
 
ABSTRACT: The cysteine accessibility method was used to explore calcium channel pore topology. Cysteine mutations were introduced into the SS1-SS2 segments of Motifs I-IV of the human cardia...

20. (Journal Article): Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH
 
ABSTRACT: 1. This study examined the action of gabapentin (gabapentin,1-(aminomethyl) cyclohexane acetic acid (Neurontin) on voltage-gated calcium (Ca(2+)) channel influx recorded in culture...