121. (Journal Article): Evidence for the impairment of the vitamin D activation pathway by cyclosporine A.

Grenet O, Bobadilla M, Chibout SD, Steiner S
 
ABSTRACT: Cyclosporine A (CsA) is a potent immunosuppressant with the drawback of renal side effects. We reported that CsA markedly decreases calcium-binding protein calbindin-D28k mRNA leve...

122. (Journal Article): Ethnicity and cardiovascular disease. The incidence of myocardial infarction in white, South Asian, and Afro-Caribbean patients with type 2 diabetes (U.K. Prospective Diabetes Study 32)

No indication of authors
 
ABSTRACT: OBJECTIVE: To estimate the incidence of myocardial infarction (MI) by ethnicity in subjects with diabetes and to examine the effect of ethnicity, adjusting for differences in cardi...

123. (Journal Article): Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion.

Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B
 
ABSTRACT: betaTC-tet cells are conditionally immortalized pancreatic beta cells which can confer long-term correction of hyperglycemia when transplanted in syngeneic streptozocin diabetic mi...

124. (Journal Article): Adenoviral gene transfer of erythropoietin confers cytoprotection to isolated pancreatic islets.

Fenjves ES, Ochoa MS, Gay-Rabinstein C, Molano RD, Pileggi A, Mendez AJ, Inverardi L, Ricordi C
 
ABSTRACT: BACKGROUND: The transfer of cytoprotective genes to isolated pancreatic islets may contribute to their enhanced survival in the transplant setting. Our laboratory established the e...

125. (Journal Article): Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound.

Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD
 
ABSTRACT: The most commonly used technical approach to isolate human pancreatic islets intended for allotransplants generates a product that is hampered by mechanical and chemical insults, w...

126. (Journal Article): Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

Sanes JR, Rubenstein JL, Nicolas JF
 
ABSTRACT: We show that a gene introduced into cells of mouse embryos by a retrovirus can serve as a heritable marker for the study of cell lineage in vivo. We constructed a defective recombi...

127. (Journal Article): Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive drugs on insulin secretion and cell viability of isolated human islets.

Hui H, Khoury N, Zhao X, Balkir L, D’Amico E, Bullotta A, Nguyen ED, Gambotto A, Perfetti R
 
ABSTRACT: Immunosuppressive drugs are routinely used to provide tolerance after whole pancreas and islet cell transplantations. While they are essential in inhibiting graft rejection, little...

128. (Journal Article): Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles

Huxtable SJ, Saker PJ, Haddad L, Walker M, Frayling TM, Levy JC, Hitman GA, O'Rahilly S, Hattersley AT, McCarthy MI
 
ABSTRACT: Variation at the variable number tandem repeat (VNTR) minisatellite 5' of the insulin gene (INS) is associated with several phenotypes, including type 1 diabetes, polycystic ovary ...

129. (Journal Article): Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy

Moczulski DK, Grzeszczak W, Gawlik B
 
ABSTRACT: OBJECTIVE: In patients with clinical hemochromatosis, the frequency of diabetes ranges from 20 to 50%, and the heterozygosity for the C282Y mutation in the HFE gene might be associ...

130. (Journal Article): Calmodulin-induced early-onset diabetes in transgenic mice.

Epstein PN, Overbeek PA, Means AR
 
ABSTRACT: Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of ...