231. (Journal Article): Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas.

Humphrey RK, Bucay N, Beattie GM, Lopez A, Messam CA, Cirulli V, Hayek A
 
ABSTRACT: Studies using adult human islets and mouse embryonic stem cells have suggested that the neurepithelial precursor cell marker nestin also identifies and can be used to purify beta-c...

232. (Journal Article): Nestin expression in pancreatic exocrine cell lineages.

Delacour A, Nepote V, Trumpp A, Herrera PL
 
ABSTRACT: Expression of nestin has been suggested to be a characteristic of pancreatic islet stem cells. To determine whether nestin is indeed expressed in such putative cells during embryon...

233. (Journal Article): Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas.

Wang S, Beattie GM, Mally MI, Cirulli V, Itkin-Ansari P, Lopez AD, Hayek A, Levine F
 
ABSTRACT: Pancreatic cell lines are useful for basic studies of pancreatic biology and for possible application to cell transplantation therapies for diabetes. A retroviral vector expressing...

234. (Journal Article): Effect of oxygen levels in villous trophoblast apoptosis.

Kilani RT, Mackova M, Davidge ST, Guilbert LJ
 
ABSTRACT: In pregnancies complicated by intrauterine growth restriction (IUGR), the villous trophoblast shows increased apoptosis and immature cytotrophoblasts (CT) may be exposed to both hi...

235. (Journal Article): Encapsulated, genetically modified cells producing in vivo therapeutics.

Hauser O, Prieschl-Grassauer E, Salmons B
 
ABSTRACT: The ability to implant genetically modified cells in immuno-isolating materials has much potential for therapeutic use. This review presents the different types of polymer that can...

236. (Journal Article): Islet abnormalities in the pathogenesis of autoimmune diabetes.

Rosmalen JG, Leenen PJ, Pelegri C, Drexhage HA, Homo-Delarche F
 
ABSTRACT: Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease that results in the destruction of the insulin-producing beta cells in the pancreatic islets of Langerhans. In spit...

237. (Journal Article): Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese zucker and sprague-dawley rats: implications of decreased glucuronidation in obese zucker rats

Kim MS, Wang S, Shen Z, Kochansky CJ, Strauss JR, Franklin RB, Vincent SH
 
ABSTRACT: Genetically obese Zucker rats exhibit symptoms similar to those of obese patients with insulin-resistance or Type II diabetes; therefore, they have been used as a genetic model to ...

238. (Journal Article): A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1

Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M
 
ABSTRACT: BACKGROUND: ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mu...

239. (Journal Article): Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.

Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Tsukiyama K, Suzuki H, Kawasaki Y, Shimodaira M, Matsuoka K, Shibata T, Kasai Y, Maekawa T, Shapiro J, Tanaka K
 
ABSTRACT: Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a succ...

240. (Journal Article): Islet isolation assessment in man and large animals.

Ricordi C, Gray DW, Hering BJ, Kaufman DB, Warnock GL, Kneteman NM, Lake SP, London NJ, Socci C, Alejandro R
 
ABSTRACT: Recent progress in islet isolation from the pancreas of large mammals including man, accentuated the need for the development of precise and reproducible techniques to assess islet...