241. (Journal Article): Insulin independence after living-donor distal pancreatectomy and islet allotransplantation.

Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Tsukiyama K, Suzuki H, Kawasaki Y, Shimodaira M, Matsuoka K, Shibata T, Kasai Y, Maekawa T, Shapiro J, Tanaka K
 
ABSTRACT: Rising demand for islet transplantation will lead to severe donor shortage in the near future, especially in countries where cadaveric organ donation is scarce. We undertook a succ...

242. (Journal Article): A new subtype of autosomal dominant diabetes attributable to a mutation in the gene for sulfonylurea receptor 1

Huopio H, Otonkoski T, Vauhkonen I, Reimann F, Ashcroft FM, Laakso M
 
ABSTRACT: BACKGROUND: ATP-sensitive potassium (KATP) channels are major regulators of glucose-induced insulin secretion in pancreatic beta cells. We have described a dominant heterozygous mu...

243. (Journal Article): Differences in the pharmacokinetics of peroxisome proliferator-activated receptor agonists in genetically obese zucker and sprague-dawley rats: implications of decreased glucuronidation in obese zucker rats

Kim MS, Wang S, Shen Z, Kochansky CJ, Strauss JR, Franklin RB, Vincent SH
 
ABSTRACT: Genetically obese Zucker rats exhibit symptoms similar to those of obese patients with insulin-resistance or Type II diabetes; therefore, they have been used as a genetic model to ...

244. (Journal Article): Effect of oxygen levels in villous trophoblast apoptosis.

Kilani RT, Mackova M, Davidge ST, Guilbert LJ
 
ABSTRACT: In pregnancies complicated by intrauterine growth restriction (IUGR), the villous trophoblast shows increased apoptosis and immature cytotrophoblasts (CT) may be exposed to both hi...

245. (Journal Article): Pancreas: how to get there from the gut?

Edlund H
 
ABSTRACT: All pancreatic cell types derive from the same endodermal dorsal and ventral anlage that grow together to form the definitive pancreas. A number of distinct transcription factors o...

246. (Journal Article): Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter.

Lechner A, Leech CA, Abraham EJ, Nolan AL, Habener JF
 
ABSTRACT: The disease diabetes mellitus arises as a consequence of a failure of the beta-cells in the islets of Langerhans of the pancreas to produce insulin in the amounts required to meet ...

247. (Journal Article): Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues.

Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N, Honjo T
 
ABSTRACT: PD-1 is a member of the immunoglobulin superfamily expressed on immune cells, including T and B cells, and is involved in the delivery of inhibitory signal upon engagement of its l...

248. (Journal Article): Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats.

Li XM.
 
ABSTRACT: Fruit from Lycium barbarum L. in the family Solanaceae is well-known in traditional Chinese herbal medicine. Lycium barbarum polysaccharides (LBP) have been identified as one of th...

249. (Journal Article): Adherence to Guidelines and its Effects on Hospitalizations with Complications of Type 2 Diabetes

Sloan FA, Bethel MA, Lee PP, Brown DS, Feinglos MN
 
ABSTRACT: OBJECTIVES: To study the discrepancy between actual and recommended rates of use among several measures of screening for complications of diabetes in a national longitudinal sample...

250. (Journal Article): A Single Treatment with IL-4 via Retrovirally Transduced Lymphocytes Partially Protects Against Diabetes in BioBreeding (BB) Rats

Zipris D, Karnieli E
 
ABSTRACT: CONTEXT: Type 1 diabetes mellitus is a T cell mediated autoimmune disease with no known methods of prevention. The BioBreeding rat is used as an animal model for the study of human...