71. (Journal Article): Enriched Human Pancreatic Ductal Cultures Obtained from Selective Death of Acinar Cells Express Pancreatic and Duodenal Homeobox Gene-1 Age-Dependently

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS
 
ABSTRACT: Adult pancreatic ductal cells are believed to be islet precursors. Our aim was to obtain an enriched human ductal cell population in defined culture conditions, and to characterize...

72. (Journal Article): In vitro study of elements in herbal remedies.

Szentmihalyi K,, Hajdu M, Fodor J, Kotai L, Blazovics A, Somogyi A, Then M.
 
ABSTRACT: Decreased glucose tolerance is a first sign of diabetes mellitus and therefore rigorous control must be taken in carbohydrate and lipid metabolisms. Herbal remedies (lyophilized ex...

73. (Journal Article): XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes

Emamaullee JA, Rajotte RV, Liston P, Korneluk RG, Lakey JR, Shapiro AM, Elliott JF
 
ABSTRACT: The Edmonton Protocol for treatment of type 1 diabetes requires islets from two or more donors to achieve euglycemia in a single recipient, primarily because soon after portal infu...

74. (Journal Article): Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact.

Beattie GM, Rubin JS, Mally MI, Otonkoski T, Hayek A
 
ABSTRACT: Ex vivo expansion of human fetal pancreatic endocrine cells is important for biological studies and as a potential tissue source for transplantation in insulin-deficient states. In...

75. (Journal Article): Prevalence of Type 2 Diabetic Patients Within the Targets of Care Guidelines in Daily Clinical Practice: A Multi-Center Study in Brazil

Gomes MB, Gianella D, Faria M, Tambascia M, Fonseca RM, Rea R, Macedo G, Filho JM, Schmid H, Bittencourt AV, Cavalcanti S, Rassi N, Pedrosa H, Dib SA
 
ABSTRACT: Major clinical studies have shown that the targets for blood glucose, lipid profile and blood pressure in type 2 diabetic patients are difficult to maintain in clinical practice. H...

76. (Journal Article): Insulin production by human embyronic stem cells.

Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL
 
ABSTRACT: Type 1 diabetes generally results from autoimmune destruction of pancreatic islet beta-cells, with consequent absolute insulin deficiency and complete dependence on exogenous insul...

77. (Journal Article): Association between Ala-9Val polymorphism of Mn-SOD gene and schizophrenia.

Akyol O, Yanik M, Elyas H, Namli M, Canatan H, Akin H, Yuce H, Yilmaz HR, Tutkun H, Sogut S, Herken H, Ozyurt H, Savas HA, Zoroglu SS
 
ABSTRACT: Reactive oxygen species (ROS) have been suggested to play an important role in physiopathology of schizophrenia. The major intracellular antioxidant enzymes, copper-zinc superoxide...

78. (Journal Article): Analysis of mitochondrial targeting sequence and coding region polymorphisms of the manganese superox-ide dismutase gene in German Parkinson disease patients.

Grasbon-Frodl EM, Kosel S, Riess O, Muller U, Mehraein P, Graeber MB
 
ABSTRACT: Two polymorphisms of the MnSOD gene, Ile58Thr and Ala9Val, have been associated with Parkinson disease (PD). The Ile58Thr amino acid exchange affects the stability at the tetrameri...

79. (Journal Article): Early glycemic control, age at onset, and development of microvascular complications in childhood-onset type 1 diabetes: a population-based study in northern Sweden.

Svensson M, Eriksson JW, Dahlquist G
 
ABSTRACT: OBJECTIVE: The aim of this work was to study the impact of glycemic control (HbA(1c)) early in disease and age at onset on the occurrence of incipient diabetic nephropathy (MA) and...

80. (Journal Article): Restoration of self-tolerance is a feasible approach to control ongoing beta-cell specific autoreactivity: its relevance for treatment in established diabetes and islet transplantation

Chatenoud L
 
ABSTRACT: Major progress has been made over the last 10 years in understanding the immune mechanisms underlying autoimmune Type I (insulin-dependent) diabetes mellitus. It seems that immunot...