91. (Journal Article): In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: relevance to the etiology of diabetic teratogenesis.

Torchinsky A, Toder V, Carp H, Orenstein H, Fein A
 
ABSTRACT: The present study was carried out to evaluate whether hyperglycemia-induced major fetal anomalies are thresholded phenomena. Streptozotocin (STZ)-treated female ICR mice were exami...

92. (Journal Article): Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-κB Activity in Embryos

Mammon K, Keshet R, Savion S, Pekar O, Zaslavsky Z, Fein A, Toder V, Torchinsky A
 
ABSTRACT: BACKGROUND: Mechanisms underlying diabetes-induced fetal growth retardation remain largely undefined. Two events such as the persistent activation of apoptosis or suppression of ce...

93. (Journal Article): NF-kappaB DNA-binding activity in embryos responding to a teratogen, cyclophosphamide.

Torchinsky A, Lishanski L, Wolstein O, Shepshelovich J, Orenstein H, Savion S, Zaslavsky Z, Carp H, Brill A, Dikstein R, Toder V, Fein A
 
ABSTRACT: BACKGROUND: The Rel/NF-kappaB transcription factors have been shown to regulate apoptosis in different cell types, acting as inducers or blockers in a stimuli- and cell type-depend...

94. (Journal Article): Engineering pancreatic islets.

Soria B, Andreu E, Berna G, Fuentes E, Gil A, Leon-Quinto T, Martin F, Montaya E, Nadal A, Reig JA, Ripoll C, Roche E, Sanches-Andres J
 
ABSTRACT: Pancreatic islets are neuroendocrine organs that control blood glucose homeostasis. The precise interplay of a heterogeneous group of cell populations (beta, alpha, delta and PP ce...

95. (Journal Article): Human islet glucokinase gene: isolation and sequence analysis of full-length cDNA.

Koranyi LI, Tanizawa Y, Welling CM, Rabin DU, Permutt MA
 
ABSTRACT: Pancreatic islet glucokinase (ATP:D-hexose-6-phosphotransferase) cDNAs were isolated from a human islet cDNA library in lambda-gt11. One clone (hlGLK2), 2723 bp plus additional pol...

96. (Journal Article): Rearrangements of desmosomal and cytoskeletal proteins during the transition from epithelial to fibroblastoid organization in cultured rat bladder carcinoma cells.

Boyer B, Tucker GC, Valles AM, Franke WW, Thiery JP
 
ABSTRACT: Changes of cell morphology and the state of differentiation are known to play important roles in embryogenesis as well as in carcinogenesis. Examples of particularly profound chang...

97. (Journal Article): Species differences in susceptibility of transplanted and cultured pancreatic islets to the beta-cell toxin alloxan.

Tyrberg B, Andersson A, Borg LA
 
ABSTRACT: The beta-cell toxin alloxan, which produces oxygen radicals, is a model substance in studies of type 1 diabetes. Recently, human beta-cells have been found to be relatively resista...

98. (Journal Article): Regulation of proliferation and differentiation of human fetal pancreatic islet cells by extracellular matrix, hepatocyte growth factor, and cell-cell contact.

Beattie GM, Rubin JS, Mally MI, Otonkoski T, Hayek A
 
ABSTRACT: Ex vivo expansion of human fetal pancreatic endocrine cells is important for biological studies and as a potential tissue source for transplantation in insulin-deficient states. In...

99. (Journal Article): Increased Transcriptional Preproinsulin II Beta-Cell Activity in Neonatal Nonobese Diabetic Mice: In Situ Hybridization Analysis

Throsby M, Coulaud J, Durant S, Homo-Delarche F
 
ABSTRACT: In the prediabetic nonobese diabetic (NOD) mouse, a spontaneous model of type 1 diabetes, we previously reported transient postweaning hyperinsulinemia followed by progressive isle...

100. (Journal Article): Enriched Human Pancreatic Ductal Cultures Obtained from Selective Death of Acinar Cells Express Pancreatic and Duodenal Homeobox Gene-1 Age-Dependently

Street CN, Lakey JR, Rajotte RV, Shapiro AM, Kieffer TJ, Lyon JG, Kin T, Korbutt GS
 
ABSTRACT: Adult pancreatic ductal cells are believed to be islet precursors. Our aim was to obtain an enriched human ductal cell population in defined culture conditions, and to characterize...