21. (Journal Article): NF-kappaB at the crossroads of life and death.

Karin M, Lin A
 
ABSTRACT: The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to sur...

22. (Journal Article): An essential role for Scurfin in CD4+CD25+ T regulatory cells.

Khattri R, Cox T, Yasayko SA, Ramsdell F
 
ABSTRACT: The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and en...

23. (Journal Article): Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG
 
ABSTRACT: Dysregulation of apoptosis can result in inappropriate suppression of cell death, as occurs in the development of some cancers, or in failure to control the extent of cell death, a...

24. (Journal Article): Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.

Gylvin T, Bergholdt R, Nerup J, Pociot F
 
ABSTRACT: Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokin...

25. (Journal Article): NFkappaB polymorphisms and susceptibility to type 1 diabetes.

Hegazy DM, O'Reilly DA, Yang BM, Hodgkinson AD, Millward BA, Demaine AG
 
ABSTRACT: Nuclear factor kappa B (NFkappaB) is an important transcription factor that is involved in the response to oxidative stress and inflammation. Recent studies suggest that it may be ...

26. (Journal Article): Beginning at the end with SUMO.

Matunis MJ, Pickart CM
 
ABSTRACT: The crystal structure of a four-protein complex comprising a SUMO ligase (E3), a SUMOylated protein substrate, and the cognate SUMO-conjugating enzyme sheds new light on catalysis,...

27. (Journal Article): SUMO: a regulator of gene expression and genome integrity.

Muller S, Ledl A, Schmidt D
 
ABSTRACT: Post-translational modification with the ubiquitin-like SUMO protein is involved in the regulation of many cellular key processes. The SUMO system modulates signal transduction pat...

28. (Journal Article): Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

Kosoy R, Concannon P
 
ABSTRACT: Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk fo...

29. (Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
 
ABSTRACT: Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...

30. (Journal Article): Assessing the validity of the association be-tween the SUMO4 M55V variant and risk of type 1 diabetes.

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.
 
ABSTRACT: Not available.