(Journal Article): NF-kappaB at the crossroads of life and death.
 
Karin M, Lin A (Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA., karinoffice@ucsd.edu )
 
IN: Nat Immunol 2002; 3(3):221-227
Impact Factor(s) of Nat Immunol: 27.011 (2005), 27.586 (2004), 28.18 (2003), 27.868 (2002), 17.431 (2001)

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ABSTRACT: The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to survive and proliferate in response to infection, whereas those that are self-reactive are eliminated via apoptosis. Even the survival of alloreactive T cells requires their proper costimulation and, when infection subsides, the activated T cells are eliminated. A major regulator of such life or death decisions is the transcription factor NF-kappaB. However, NF-kappaB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate.

TYPE OF PUBLICATION: Review

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• Mammon K, Keshet R, Savion S, Pekar O, Zaslavsky Z, Fein A, Toder V, Torchinsky A. Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-κB Activity in Embryos. Rev Diabetic Stud 2005. 2: 27-34.
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