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Your search for: 'Nature*' |
Documents 1 - 10 of 76 matches |
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1. (Journal Article): Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
Contreras JL, Wu H, Smyth CA, Eckstein CP, Young CJ, Seki T, Bilbao G, Curiel DT, Eckhoff DE ABSTRACT:
BACKGROUND: New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The abilit...
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Diabetes OD
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Regeneration of Isle...
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Transplantation
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Islet Cells
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Follow-up
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Islet Cell Graft Fun...
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Preserving and Enhan...
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Genetic Modification
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Methods and Vehicles
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Adenovirus
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Transfection Efficie...
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Journal Article
submitted: Jan 15, 2006 |
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2. (Journal Article): A role for glucagon-like peptide-1 in the central regula-tion of feeding.
Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR ABSTRACT:
The sequence of glucagon-like peptide-1 (7-36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role. We have...
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Diabetes OD
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Reversal/Prevention ...
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T2DM
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Insulinotropic Subst...
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Incretins
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GLP-1
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Journal Article
submitted: Nov 16, 2005 |
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3. (Journal Article): TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.
Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L ABSTRACT:
CD3-specific antibodies have the unique capacity to restore self-tolerance in established autoimmunity. They induce long-term remission of overt diabetes in nonobese diabetic (NOD)...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Re-establishing Tole...
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Induction of Natural...
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Tolerance Induction
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CD3-ε antibodie...
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Journal Article
submitted: May 26, 2005 |
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4. (Journal Article): Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells.
Weiner HL ABSTRACT:
Oral tolerance is a long recognized method to induce peripheral immune tolerance. Oral tolerance has been used successfully to treat animal models of autoimmune diseases and is bei...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Re-establishing Tole...
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Modifying Immunity
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Oral Tolerization
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TGF-beta-secretion
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Journal Article
submitted: May 25, 2005 |
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5. (Journal Article): Insulin-dependent diabetes mellitus as an autoimmune disease.
Bach JF ABSTRACT:
IDDM is unquestionably an autoimmune disease, as reflected by the presence of beta-cell-reactive autoantibodies and T cells, T cell-mediated transfer of the disease in nondiabetic ...
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Diabetes OD
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Reversal/Prevention ...
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T1DM
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Re-establishing Tole...
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Modifying Immunity
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Recent Onset
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Systemic Interventio...
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T cells
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Anti-CD3 Therapy
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Journal Article
submitted: Dec 04, 2005 |
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6. (Journal Article): Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections
King H, Aubert RE, Herman WH ABSTRACT:
OBJECTIVE: To estimate the prevalence of diabetes and the number of people with diabetes who are > or =20 years of age in all countries of the world for three points in time, i....
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Diabetes OD
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Diabetes Pathogenesi...
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Epidemiology
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Journal Article
submitted: Sep 22, 2004 |
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7. (Journal Article): Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion
Ballinger SW, Shoffner JM, Hedaya EV, Trounce I, Polak MA, Koontz DA, Wallace DC ABSTRACT:
Diabetes mellitus (DM) is one of the most common chronic disorders of children and adults. Several reports have suggested an increased incidence of maternal transmission in some fo...
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Diabetes OD
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Diabetes Pathogenesi...
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Genetics
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Journal Article
submitted: Dec 18, 2004 |
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8. (Journal Article): The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3.
Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, Kelly TE, Saulsbury FT, Chance PF, Ochs HD ABSTRACT:
IPEX is a fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM 304930). We present genetic evidence that different mu...
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Diabetes OD
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Diabetes Pathogenesi...
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T1DM
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Genes
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FOXP3
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IPEX
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Journal Article
submitted: May 25, 2005 |
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9. (Journal Article): Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F |
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Diabetes OD
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Diabetes Pathogenesi...
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T1DM
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Genes
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FOXP3
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Journal Article
submitted: May 25, 2005 |
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10. (Journal Article): Assessing the validity of the association be-tween the SUMO4 M55V variant and risk of type 1 diabetes.
Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA. ABSTRACT:
Not available.
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Diabetes OD
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Diabetes Pathogenesi...
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T1DM
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Autoimmunity
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Genetics of Autoimmu...
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SUMO4
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Polymorphism
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Journal Article
submitted: Aug 24, 2005 |
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