61. (Journal Article): The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES
 
ABSTRACT: Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in mu...

62. (Journal Article): Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI
 
ABSTRACT: Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifact...

63. (Journal Article): Pancreatic Head Mass: What Can Be Done? Classification: The Clinical Point of View

Pulay I, Tihanyi TF, Flautner L
 
ABSTRACT: Surgeons frequently find pancreatic head mass when operating. The obvious difficulty is to make the correct preoperative differential diagnosis between chronic pancreatitis and pan...

64. (Journal Article): Reversal of insulin-dependent diabetes using islet cells generated in vitro from pancreatic stem cells.

Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG
 
ABSTRACT: Ductal structures of the adult pancreas contain stem cells that differentiate into islets of Langerhans. Here, we grew pancreatic ductal epithelial cells isolated from prediabetic ...

65. (Journal Article): Insulin-promoter-factor 1 is required for pancreas development in mice.

Jonsson J, Carlsson L, Edlund T, Edlund H
 
ABSTRACT: The mammalian pancreas is a mixed exocrine and endocrine gland that, in most species, arises from ventral and dorsal buds which subsequently merge to form the pancreas. In both mou...

66. (Journal Article): Remission in models of type 1 diabetes by gene therapy using a single chain insulin-analogue.

Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW
 
ABSTRACT: A cure for diabetes has long been sought using several different approaches, including islet transplantation, regeneration of beta cells and insulin gene therapy. However, permanen...

67. (Journal Article): A proton pore in a potassium channel voltage sensor reveals a focused electric field.

Starace DM, Bezanilla F
 
ABSTRACT: Voltage-dependent potassium channels are essential for the generation of nerve impulses. Voltage sensitivity is conferred by charged residues located mainly in the fourth transmemb...

68. (Journal Article): Adult pancreatic beta-cells are formed by self-duplication rather than stem cell differentiation.

Dor Y, Brown J, Martinez OI, Melton DA
 
ABSTRACT: How tissues generate and maintain the correct number of cells is a fundamental problem in biology. In principle, tissue turnover can occur by the differentiation of stem cells, as ...

69. (Journal Article): Notch signalling controls pancreatic cell differentiation.

Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H
 
ABSTRACT: The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms controlling the differentiation of these cell types are largely unknown. Despite their endoder...

70. (Journal Article): Attenuation of FGF signaling in mouse beta-cells leads to diabetes.

Hart AW, Baeza N, Apelqvist A, Edlund H
 
ABSTRACT: Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many organs, including the developing pancreas. Here we show ...