51. (Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
 
ABSTRACT: Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...

52. (Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
 
ABSTRACT: Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...

53. (Journal Article): Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

Halban PA
 
ABSTRACT: Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration ...

54. (Journal Article): Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro.

Reubinoff BE, Pera MF, Fong CY, Trounson A, Bongso A
 
ABSTRACT: We describe the derivation of pluripotent embryonic stem (ES) cells from human blastocysts. Two diploid ES cell lines have been cultivated in vitro for extended periods while maint...

55. (Journal Article): Effect of metabolic acidosis on the growth hormone/IGF endocrine axis in skeletal growth centers.

Green J, Maor G
 
ABSTRACT: BACKGROUND: Chronic metabolic acidosis (CMA) adversely affects bone metabolism and skeletal growth. Given the cardinal role played by the local growth hormone (GH)/insulin-like gro...

56. (Journal Article): Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.

Niwa H, Miyazaki J, Smith AG
 
ABSTRACT: Cell fate during development is defined by transcription factors that act as molecular switches to activate or repress specific gene expression programmes. The POU transcription fa...

57. (Journal Article): A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG
 
ABSTRACT: Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to...

58. (Journal Article): Association of class I major histocompatibility heavy and light chains induced by viral peptides.

Townsend A, Ohlen C, Bastin J, Ljunggren HG, Foster L, Karre K
 
ABSTRACT: We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleopro...

59. (Journal Article): The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES
 
ABSTRACT: Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in mu...

60. (Journal Article): Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M, Hinokio Y, Lindner TH, Mashima H, Schwarz PE, del Bosque-Plata L, Horikawa Y, Oda Y, Yoshiuchi I, Colilla S, Polonsky KS, Wei S, Concannon P, Iwasaki N, Schulze J, Baier LJ, Bogardus C, Groop L, Boerwinkle E, Hanis CL, Bell GI
 
ABSTRACT: Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifact...