31. (Journal Article): Combined Osteoclastic Giant Cell and Pleomorphic Giant Cell Tumor of the Pancreas: A Rarity. An Immunohistochemical Analysis and Review of the Literature

Loya A, Ratnakar KS, Shastry RA
 
ABSTRACT: CONTEXT: The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome....

32. (Journal Article): Type 2 Diabetes Mellitus as a Conformational Disease

Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR
 
ABSTRACT: Conformational diseases are conditions that arise from the dysfunctional aggregation of proteins in non-native conformations. Type 2 diabetes mellitus can be defined as a conformat...

33. (Journal Article): Have We Overlooked the Importance of Serine/Threonine Protein Phosphatases in Pancreatic Beta-Cells? Role Played by Protein Phosphatase 2A in Insulin Secretion

Parameswara VK, Sule AJ, Esser V
 
ABSTRACT: Genetic predisposition and environmental influences insidiously converge to cause glucose intolerance and hyperglycemia. Beta-cell compensates by secreting more insulin and when it...

34. (Journal Article): Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.

Contreras JL, Wu H, Smyth CA, Eckstein CP, Young CJ, Seki T, Bilbao G, Curiel DT, Eckhoff DE
 
ABSTRACT: BACKGROUND: New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The abilit...

35. (Journal Article): Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells.

Weiner HL
 
ABSTRACT: Oral tolerance is a long recognized method to induce peripheral immune tolerance. Oral tolerance has been used successfully to treat animal models of autoimmune diseases and is bei...

36. (Journal Article): Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.

Brunkow ME, Jeffery EW, Hjerrild KA, Paeper B, Clark LB, Yasayko SA, Wilkinson JE, Galas D, Ziegler SF, Ramsdell F

37. (Journal Article): Assessing the validity of the association be-tween the SUMO4 M55V variant and risk of type 1 diabetes.

Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.
 
ABSTRACT: Not available.

38. (Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
 
ABSTRACT: Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...

39. (Journal Article): Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

Kosoy R, Concannon P
 
ABSTRACT: Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk fo...

40. (Journal Article): Beginning at the end with SUMO.

Matunis MJ, Pickart CM
 
ABSTRACT: The crystal structure of a four-protein complex comprising a SUMO ligase (E3), a SUMOylated protein substrate, and the cognate SUMO-conjugating enzyme sheds new light on catalysis,...