11. (Journal Article): PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CVE
 
ABSTRACT: It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in endodermal differentiation during pancreatic and duodenal development (Wright, C.V.E., Schnegelsberg, P...

12. (Journal Article): To die or not to die: the function of the transcription factor NF-kappaB in embryos exposed to stress.

Torchinsky A, Toder V
 
ABSTRACT: BACKGROUND: Cytokines operating in the embryo and embryonic microenvironment determine, to a significant extent, whether pregnancy is completed successfully or results in embryonic...

13. (Journal Article): Bone marrow-derived stem cells initiate pancreatic regeneration.

Hess D, Li L, Martin M, Sakano S, Hill D, Strutt B, Thyssen S, Gray DA, Bhatia M
 
ABSTRACT: We show that transplantation of adult bone marrow-derived cells expressing c-kit reduces hyperglycemia in mice with streptozotocin-induced pancreatic damage. Although quantitative ...

14. (Journal Article): NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.

Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L
 
ABSTRACT: To explore induced islet neogenesis in the liver as a strategy for the treatment of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the pancreatic duodenal homeobox...

15. (Journal Article): Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.

Fontenot JD, Gavin MA, Rudensky AY
 
ABSTRACT: CD4+CD25+ regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4+...

16. (Journal Article): NF-kappaB at the crossroads of life and death.

Karin M, Lin A
 
ABSTRACT: The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to sur...

17. (Journal Article): An essential role for Scurfin in CD4+CD25+ T regulatory cells.

Khattri R, Cox T, Yasayko SA, Ramsdell F
 
ABSTRACT: The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and en...

18. (Journal Article): Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG
 
ABSTRACT: Dysregulation of apoptosis can result in inappropriate suppression of cell death, as occurs in the development of some cancers, or in failure to control the extent of cell death, a...

19. (Journal Article): Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.

Gylvin T, Bergholdt R, Nerup J, Pociot F
 
ABSTRACT: Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokin...

20. (Journal Article): NFkappaB polymorphisms and susceptibility to type 1 diabetes.

Hegazy DM, O'Reilly DA, Yang BM, Hodgkinson AD, Millward BA, Demaine AG
 
ABSTRACT: Nuclear factor kappa B (NFkappaB) is an important transcription factor that is involved in the response to oxidative stress and inflammation. Recent studies suggest that it may be ...