41. (Journal Article): Islet Amyloid, Metabolic Syndrome, and the Natural Progressive History of Type 2 Diabetes Mellitus

Hayden MR
 
ABSTRACT: The presence of amyloid within the islet of the pancreas may be one of the best kept secrets in clinical medicine and translation of this century old finding may help to better und...

42. (Journal Article): Combined Osteoclastic Giant Cell and Pleomorphic Giant Cell Tumor of the Pancreas: A Rarity. An Immunohistochemical Analysis and Review of the Literature

Loya A, Ratnakar KS, Shastry RA
 
ABSTRACT: CONTEXT: The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome....

43. (Journal Article): Type 2 Diabetes Mellitus as a Conformational Disease

Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR
 
ABSTRACT: Conformational diseases are conditions that arise from the dysfunctional aggregation of proteins in non-native conformations. Type 2 diabetes mellitus can be defined as a conformat...

44. (Journal Article): Have We Overlooked the Importance of Serine/Threonine Protein Phosphatases in Pancreatic Beta-Cells? Role Played by Protein Phosphatase 2A in Insulin Secretion

Parameswara VK, Sule AJ, Esser V
 
ABSTRACT: Genetic predisposition and environmental influences insidiously converge to cause glucose intolerance and hyperglycemia. Beta-cell compensates by secreting more insulin and when it...

45. (Journal Article): PD-L2 is a second ligand for PD-1 and inhibits T cell activation.

Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ.
 
ABSTRACT: Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We ...

46. (Journal Article): B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.

Dong H, Zhu G, Tamada K, Chen L
 
ABSTRACT: The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated imm...

47. (Journal Article): Costimulation and Pancreatic Autoimmunity: The PD-1/PD-L Conundrum

Yadav D, Sarvetnik N
 
ABSTRACT: T cell activation is a complex process that requires a multitude of interactions between antigen-presenting cells (APC) and T cells. The primary signal is provided via the binding ...

48. (Journal Article): The principle of gating charge movement in a voltage-dependent K+ channel.

Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R
 
ABSTRACT: The steep dependence of channel opening on membrane voltage allows voltage-dependent K+ channels to turn on almost like a switch. Opening is driven by the movement of gating charge...

49. (Journal Article): Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.

Varadi G, Lory P, Schultz D, Varadi M, Schwartz A
 
ABSTRACT: The L-type voltage-dependent calcium channel is an important link in excitation-contraction coupling of muscle cells (reviewed in refs 2 and 3). The channel has two functional char...

50. (Journal Article): Insulin-promoter-factor 1 is required for pancreas development in mice.

Jonsson J, Carlsson L, Edlund T, Edlund H
 
ABSTRACT: The mammalian pancreas is a mixed exocrine and endocrine gland that, in most species, arises from ventral and dorsal buds which subsequently merge to form the pancreas. In both mou...