61. (Journal Article): Type 2 Diabetes Mellitus as a Conformational Disease

Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR
 
ABSTRACT: Conformational diseases are conditions that arise from the dysfunctional aggregation of proteins in non-native conformations. Type 2 diabetes mellitus can be defined as a conformat...

62. (Journal Article): Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.

Contreras JL, Wu H, Smyth CA, Eckstein CP, Young CJ, Seki T, Bilbao G, Curiel DT, Eckhoff DE
 
ABSTRACT: BACKGROUND: New strategies for improving durable functional islet mass will be instrumental in facilitating islet transplantation as a cure for type 1 diabetes mellitus. The abilit...

63. (Journal Article): Pancreatic and intestinal processing of proglucagon in man.

0rskov C, Holst JJ, Poulsen S, Kirkegaard P
 
ABSTRACT: We developed antisera and radioimmunoassays against synthetic replicas of glucagon-like peptide-1 (1-36) and -2, predicted products of the glucagon precursor, and against glucagon-...

64. (Journal Article): Costimulation and Pancreatic Autoimmunity: The PD-1/PD-L Conundrum

Yadav D, Sarvetnik N
 
ABSTRACT: T cell activation is a complex process that requires a multitude of interactions between antigen-presenting cells (APC) and T cells. The primary signal is provided via the binding ...

65. (Journal Article): Insulin-promoter-factor 1 is required for pancreas development in mice.

Jonsson J, Carlsson L, Edlund T, Edlund H
 
ABSTRACT: The mammalian pancreas is a mixed exocrine and endocrine gland that, in most species, arises from ventral and dorsal buds which subsequently merge to form the pancreas. In both mou...

66. (Journal Article): PD-L2 is a second ligand for PD-1 and inhibits T cell activation.

Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ.
 
ABSTRACT: Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We ...

67. (Journal Article): Combined Osteoclastic Giant Cell and Pleomorphic Giant Cell Tumor of the Pancreas: A Rarity. An Immunohistochemical Analysis and Review of the Literature

Loya A, Ratnakar KS, Shastry RA
 
ABSTRACT: CONTEXT: The combination of an osteoclastic giant cell tumor and a pleomorphic giant cell carcinoma of the pancreas is distinctly unusual and is associated with an adverse outcome....

68. (Journal Article): A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG
 
ABSTRACT: Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to the deletion of T cells and their failure to...

69. (Journal Article): Islet Redox Stress: The Manifold Toxicities of Insulin Resistance, Metabolic Syndrome and Amylin Derived Islet Amyloid in Type 2 Diabetes Mellitus

Hayden MR, Tyagi SC
 
ABSTRACT: CONTEXT: Redox stress, reactive oxygen species, reactive nitrogen species, and oxygen free radicals ('toxic oxygen') are increasingly being reported as important cellular signaling...

70. (Journal Article): GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.

Sturis J, Gotfredsen CF, Romer J, Rolin B, Ribel U, Brand CL, Wilken M, Wassermann K, Deacon CF, Carr RD, Knudsen LB
 
ABSTRACT: (1) Liraglutide is a long-acting GLP-1 derivative, designed for once daily administration in type II diabetic patients. To investigate the effects of liraglutide on glycemic contro...