11. (Journal Article): NFkappaB polymorphisms and susceptibility to type 1 diabetes.

Hegazy DM, O'Reilly DA, Yang BM, Hodgkinson AD, Millward BA, Demaine AG
 
ABSTRACT: Nuclear factor kappa B (NFkappaB) is an important transcription factor that is involved in the response to oxidative stress and inflammation. Recent studies suggest that it may be ...

12. (Journal Article): Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.

Gylvin T, Bergholdt R, Nerup J, Pociot F
 
ABSTRACT: Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokin...

13. (Journal Article): Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine.

Halban PA
 
ABSTRACT: Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration ...

14. (Journal Article): Reversal of insulin-dependent diabetes using islet cells generated in vitro from pancreatic stem cells.

Ramiya VK, Maraist M, Arfors KE, Schatz DA, Peck AB, Cornelius JG
 
ABSTRACT: Ductal structures of the adult pancreas contain stem cells that differentiate into islets of Langerhans. Here, we grew pancreatic ductal epithelial cells isolated from prediabetic ...

15. (Journal Article): Association of class I major histocompatibility heavy and light chains induced by viral peptides.

Townsend A, Ohlen C, Bastin J, Ljunggren HG, Foster L, Karre K
 
ABSTRACT: We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleopro...

16. (Journal Article): A role for glucagon-like peptide-1 in the central regula-tion of feeding.

Turton MD, O'Shea D, Gunn I, Beak SA, Edwards CM, Meeran K, Choi SJ, Taylor GM, Heath MM, Lambert PD, Wilding JP, Smith DM, Ghatei MA, Herbert J, Bloom SR
 
ABSTRACT: The sequence of glucagon-like peptide-1 (7-36) amide (GLP-1) is completely conserved in all mammalian species studied, implying that it plays a critical physiological role. We have...

17. (Journal Article): The principle of gating charge movement in a voltage-dependent K+ channel.

Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R
 
ABSTRACT: The steep dependence of channel opening on membrane voltage allows voltage-dependent K+ channels to turn on almost like a switch. Opening is driven by the movement of gating charge...

18. (Journal Article): Remission in models of type 1 diabetes by gene therapy using a single chain insulin-analogue.

Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW
 
ABSTRACT: A cure for diabetes has long been sought using several different approaches, including islet transplantation, regeneration of beta cells and insulin gene therapy. However, permanen...

19. (Journal Article): Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.

Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T
 
ABSTRACT: We have reproduced a previously described method for the in vitro generation of endocrine cells in adult human pancreatic tissue culture. The aim of this study was to characterize ...

20. (Journal Article): Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F
 
ABSTRACT: The nature and even existence of adult pancreatic endocrine stem or progenitor cells is a subject of controversy in the field of beta-cell replacement for diabetes. One place to se...