31. (Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
 
ABSTRACT: Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...

32. (Journal Article): Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG
 
ABSTRACT: Dysregulation of apoptosis can result in inappropriate suppression of cell death, as occurs in the development of some cancers, or in failure to control the extent of cell death, a...

33. (Journal Article): An essential role for Scurfin in CD4+CD25+ T regulatory cells.

Khattri R, Cox T, Yasayko SA, Ramsdell F
 
ABSTRACT: The molecular properties that characterize CD4+CD25+ regulatory T cells (TR cells) remain elusive. Absence of the transcription factor Scurfin (also known as forkhead box P3 and en...

34. (Journal Article): NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice.

Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L
 
ABSTRACT: To explore induced islet neogenesis in the liver as a strategy for the treatment of diabetes, we used helper-dependent adenovirus (HDAD) to deliver the pancreatic duodenal homeobox...

35. (Journal Article): Manganese superoxide dismutase gene polymorphism and schizophrenia: relation to tardive dyskinesia.

Hori H, Ohmori O, Shinkai T, Kojima H, Okano C, Suzuki T, Nakamura J
 
ABSTRACT: There has been increasing evidence that deranged superoxide dismutase (SOD) activities might be a risk factor for schizophrenia and/or tardive dyskinesia (TD). In the present study...

36. (Journal Article): When oral agents fail: practical barriers to starting insulin.

Korytkowski M
 
ABSTRACT: Insulin therapy has proven benefits in Type 2 diabetes patients when combination therapy has failed. However, there is some reluctance by both patients and healthcare professionals...

37. (Journal Article): Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways.

Moley KH, Chi MM, Knudson CM, Korsmeyer SJ, Mueckler MM
 
ABSTRACT: Although perinatal mortality rates have improved for pregnant diabetic women because of insulin therapy and tight metabolic control, infants of diabetics still experience significa...

38. (Journal Article): Differentiation of human embryonic stem cells into embryoid bodies compromising the three embryonic germ layers.

Itskovitz-Eldor J, Schuldiner M, Karsenti D, Eden A, Yanuka O, Amit M, Soreq H, Benvenisty N
 
ABSTRACT: BACKGROUND: Embryonic stem (ES) cells are lines of cells that are isolated from blastocysts. The murine ES cells were demonstrated to be true pluripotent cells as they differentiat...

39. (Journal Article): Cell fusion is the principal source of bone-marrow-derived hepatocytes.

Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M
 
ABSTRACT: Evidence suggests that haematopoietic stem cells might have unexpected developmental plasticity, highlighting therapeutic potential. For example, bone-marrow-derived hepatocytes ca...

40. (Journal Article): Notch signalling controls pancreatic cell differentiation.

Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H
 
ABSTRACT: The pancreas contains both exocrine and endocrine cells, but the molecular mechanisms controlling the differentiation of these cell types are largely unknown. Despite their endoder...