51. (Journal Article): PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.

Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CVE
 
ABSTRACT: It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in endodermal differentiation during pancreatic and duodenal development (Wright, C.V.E., Schnegelsberg, P...

52. (Journal Article): Novel Insights in the Regulation of the Immune System: A Report on the FASEB Summer Research Conference on Autoimmunity, 2003

Gronski MA
 
ABSTRACT: The bi-annual FASEB autoimmunity conference organized last year by Betty Diamond and Stephen Miller brought together some 150 delegates studying various aspects of autoimmune disea...

53. (Journal Article): B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.

Dong H, Zhu G, Tamada K, Chen L
 
ABSTRACT: The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated imm...

54. (Journal Article): Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion.

Dupraz P, Rinsch C, Pralong WF, Rolland E, Zufferey R, Trono D, Thorens B
 
ABSTRACT: betaTC-tet cells are conditionally immortalized pancreatic beta cells which can confer long-term correction of hyperglycemia when transplanted in syngeneic streptozocin diabetic mi...

55. (Journal Article): Attenuation of FGF signaling in mouse beta-cells leads to diabetes.

Hart AW, Baeza N, Apelqvist A, Edlund H
 
ABSTRACT: Fibroblast growth factor (FGF) signalling has been implicated in patterning, proliferation and cell differentiation in many organs, including the developing pancreas. Here we show ...

56. (Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
 
ABSTRACT: Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...

57. (Journal Article): Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin induced hyperglycemia.

Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N, Karasik A
 
ABSTRACT: Insulin gene expression is restricted to islet beta cells of the mammalian pancreas through specific control mechanisms mediated in part by specific transcription factors. The prot...

58. (Journal Article): Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.

Varadi G, Lory P, Schultz D, Varadi M, Schwartz A
 
ABSTRACT: The L-type voltage-dependent calcium channel is an important link in excitation-contraction coupling of muscle cells (reviewed in refs 2 and 3). The channel has two functional char...

59. (Journal Article): Have We Overlooked the Importance of Serine/Threonine Protein Phosphatases in Pancreatic Beta-Cells? Role Played by Protein Phosphatase 2A in Insulin Secretion

Parameswara VK, Sule AJ, Esser V
 
ABSTRACT: Genetic predisposition and environmental influences insidiously converge to cause glucose intolerance and hyperglycemia. Beta-cell compensates by secreting more insulin and when it...

60. (Journal Article): Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections

King H, Aubert RE, Herman WH
 
ABSTRACT: OBJECTIVE: To estimate the prevalence of diabetes and the number of people with diabetes who are > or =20 years of age in all countries of the world for three points in time, i....