41. (Journal Article): When oral agents fail: practical barriers to starting insulin.

Korytkowski M
 
ABSTRACT: Insulin therapy has proven benefits in Type 2 diabetes patients when combination therapy has failed. However, there is some reluctance by both patients and healthcare professionals...

42. (Journal Article): Adult pancreatic beta-cells are formed by self-duplication rather than stem cell differentiation.

Dor Y, Brown J, Martinez OI, Melton DA
 
ABSTRACT: How tissues generate and maintain the correct number of cells is a fundamental problem in biology. In principle, tissue turnover can occur by the differentiation of stem cells, as ...

43. (Journal Article): Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation.

Dor Y, Brown J, Martinez OI, Melton DA
 
ABSTRACT: How tissues generate and maintain the correct number of cells is a fundamental problem in biology. In principle, tissue turnover can occur by the differentiation of stem cells, as ...

44. (Journal Article): Islet Amyloid, Metabolic Syndrome, and the Natural Progressive History of Type 2 Diabetes Mellitus

Hayden MR
 
ABSTRACT: The presence of amyloid within the islet of the pancreas may be one of the best kept secrets in clinical medicine and translation of this century old finding may help to better und...

45. (Journal Article): Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes.

Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD
 
ABSTRACT: OBJECTIVE: This study evaluated the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing maximally effective d...

46. (Journal Article): Effects of exenatide (exendin-4) on glycemic con-trol and weight over 30 weeks in metformin-treated patients with type 2 diabetes.

DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD
 
ABSTRACT: OBJECTIVE: This study evaluates the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients with type 2 diabetes failing to achieve glycemic c...

47. (Journal Article): Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.

Niwa H, Miyazaki J, Smith AG
 
ABSTRACT: Cell fate during development is defined by transcription factors that act as molecular switches to activate or repress specific gene expression programmes. The POU transcription fa...

48. (Journal Article): To die or not to die: the function of the transcription factor NF-kappaB in embryos exposed to stress.

Torchinsky A, Toder V
 
ABSTRACT: BACKGROUND: Cytokines operating in the embryo and embryonic microenvironment determine, to a significant extent, whether pregnancy is completed successfully or results in embryonic...

49. (Journal Article): B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.

Dong H, Zhu G, Tamada K, Chen L
 
ABSTRACT: The B7 family members B7-1 and B7-2 interact with CD28 and constitute an essential T-cell co-stimulatory pathway in the initiation of antigen-specific humoral and cell-mediated imm...

50. (Journal Article): Cell fusion-independent differentiation of neural stem cells to the endothelial lineage.

Wurmser AE, Nakashima K, Summers RG, Toni N, D'Amour KA, Lie DC, Gage FH
 
ABSTRACT: Somatic stem cells have been claimed to possess an unexpectedly broad differentiation potential (referred to here as plasticity) that could be induced by exposing stem cells to the...