21. (Journal Article): Characterization of endocrine progenitor cells and critical factors for their differentiation in human adult pancreatic cell culture.

Gao R, Ustinov J, Pulkkinen MA, Lundin K, Korsgren O, Otonkoski T
 
ABSTRACT: We have reproduced a previously described method for the in vitro generation of endocrine cells in adult human pancreatic tissue culture. The aim of this study was to characterize ...

22. (Journal Article): Remission in models of type 1 diabetes by gene therapy using a single chain insulin-analogue.

Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW
 
ABSTRACT: A cure for diabetes has long been sought using several different approaches, including islet transplantation, regeneration of beta cells and insulin gene therapy. However, permanen...

23. (Journal Article): The principle of gating charge movement in a voltage-dependent K+ channel.

Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R
 
ABSTRACT: The steep dependence of channel opening on membrane voltage allows voltage-dependent K+ channels to turn on almost like a switch. Opening is driven by the movement of gating charge...

24. (Journal Article): Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

Ballinger SW, Shoffner JM, Hedaya EV, Trounce I, Polak MA, Koontz DA, Wallace DC
 
ABSTRACT: Diabetes mellitus (DM) is one of the most common chronic disorders of children and adults. Several reports have suggested an increased incidence of maternal transmission in some fo...

25. (Journal Article): The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES
 
ABSTRACT: Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in mu...

26. (Journal Article): NF-kappaB at the crossroads of life and death.

Karin M, Lin A
 
ABSTRACT: The choice between life and death is one of the major events in regulation of the immune system. T cells that specifically recognize viral or bacterial antigens are selected to sur...

27. (Journal Article): A proton pore in a potassium channel voltage sensor reveals a focused electric field.

Starace DM, Bezanilla F
 
ABSTRACT: Voltage-dependent potassium channels are essential for the generation of nerve impulses. Voltage sensitivity is conferred by charged residues located mainly in the fourth transmemb...

28. (Journal Article): TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes.

Belghith M, Bluestone JA, Barriot S, Megret J, Bach JF, Chatenoud L
 
ABSTRACT: CD3-specific antibodies have the unique capacity to restore self-tolerance in established autoimmunity. They induce long-term remission of overt diabetes in nonobese diabetic (NOD)...

29. (Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.

Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
 
ABSTRACT: Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...

30. (Journal Article): Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.

Liston P, Roy N, Tamai K, Lefebvre C, Baird S, Cherton-Horvat G, Farahani R, McLean M, Ikeda JE, MacKenzie A, Korneluk RG
 
ABSTRACT: Dysregulation of apoptosis can result in inappropriate suppression of cell death, as occurs in the development of some cancers, or in failure to control the extent of cell death, a...