(Journal Article): Sequence and expression of mRNAs encoding the alpha 1 and alpha 2 subunits of a DHP-sensitive calcium channel.
Ellis SB, Williams ME, Ways NR, Brenner R, Sharp AH, Leung AT, Campbell KP, McKenna E, Koch WJ, Hui A
IN:
Science
1988; 241(4873):1661-1664
Impact Factor(s) of Science: 30.927 (2005), 31.853 (2004), 29.162 (2003), 26.682 (2002), 23.329 (2001)
ABSTRACT: Complementary DNAs were isolated and used to deduce the primary structures of the alpha 1 and alpha 2 subunits of the dihydropyridine-sensitive, voltage-dependent calcium channel f... Click HERE for details
(Journal Article): Molecular pharmacology of voltage-dependent calcium channels.
Mori Y
IN:
Jpn J Pharmacol
1996; 72(2):83-109
Impact Factor(s) of Jpn J Pharmacol: 1.724 (2004), 1.23 (2002), 1.347 (2001)
(Journal Article): Structure and regulation of voltage-gated Ca2+ channels.
Catterall WA
IN:
Annu Rev Cell Dev Biol
2000; 16(1):521-555
Impact Factor(s) of Annu Rev Cell Dev Biol: 23.69 (2005), 17.804 (2004), 22.638 (2003), 22.87 (2002), 27.106 (2001)
ABSTRACT: Voltage-gated Ca(2+) channels mediate Ca(2+) entry into cells in response to membrane depolarization. Electrophysiological studies reveal different Ca(2+) currents designated L-, N... Click HERE for details
(Journal Article): Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit.
Rottbauer W, Baker K, Wo ZG, Mohideen MA, Cantiello HF, Fishman MC
IN:
Dev Cell
2001; 1(2):265-275
Impact Factor(s) of Dev Cell: 15.434 (2004), 14.807 (2003), 11.531 (2002)
ABSTRACT: The heart must function from the moment of its embryonic assembly, but the molecular underpinnings of the first heart beat are not known, nor whether function determines form at th... Click HERE for details
(Journal Article): Direct interaction of gbetagamma with a C-terminal gbetagamma-binding domain of the Ca2+ channel alpha1 subunit is responsible for channel inhibition by G protein-coupled receptors.
Qin N, Platano D, Olcese R, Stefani E, Birnbaumer L
IN:
Proc Natl Acad Sci U S A
1997; 94(16):8866-8871
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
ABSTRACT: Several classes of voltage-gated Ca2+ channels (VGCCs) are inhibited by G proteins activated by receptors for neurotransmitters and neuromodulatory peptides. Evidence has accumulat... Click HERE for details
(Journal Article): Mechanism of SNARE protein binding and regulation of Cav2 channels by phosphorylation of the synaptic protein interaction site.
Yokoyama CT, Myers SJ, Fu J, Mockus SM, Scheuer T, Catterall WA
IN:
Mol Cell Neurosci
2005; 28(1):1-17
Impact Factor(s) of Mol Cell Neurosci: 3.789 (2004), 4.231 (2003), 5.446 (2001)
ABSTRACT: Ca(v)2.1 and Ca(v)2.2 channels conduct P/Q-type and N-type Ca(2+) currents that initiate neurotransmission and bind SNARE proteins through a synaptic protein interaction (synprint)... Click HERE for details
(Journal Article): Molecular physiology of low-voltage-activated t-type calcium channels.
Perez-Reyes E
IN:
Physiol Rev
2003; 83:117-161
Impact Factor(s) of Physiol Rev: 28.721 (2005), 33.918 (2004), 36.831 (2003), 26.532 (2002), 30.061 (2001)
ABSTRACT: T-type Ca2+ channels were originally called low-voltage-activated (LVA) channels because they can be activated by small depolarizations of the plasma membrane. In many neurons Ca2+... Click HERE for details
(Journal Article): Cloning of a novel four repeat protein related to voltage-gated sodium and calcium channels.
Lee JH, Cribbs LL, Perez-Reyes E
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FEBS Lett
1999; 445(2-3):231-236
Impact Factor(s) of FEBS Lett: 3.843 (2004), 3.609 (2003), 3.912 (2002), 3.644 (2001)
ABSTRACT: Cloning has led to the discovery of more ion channels than predicted by functional studies, yet there remain channels that have not been cloned. We report the cloning of a novel pr... Click HERE for details
(Journal Article): Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: studies with antibodies against the alpha subunits.
Takahashi M, Catterall WA
IN:
Biochemistry
1987; 26(17):5518-5526
Impact Factor(s) of Biochemistry: 4.008 (2004), 3.922 (2003), 4.114 (2001)
ABSTRACT: Polyclonal antibodies (PAC-2) against the purified skeletal muscle calcium channel were prepared and shown to be directed against alpha subunits of this protein by immunoblotting a... Click HERE for details
(Journal Article): Differences in apparent pore sizes of low and high voltage-activated Ca2+ channels.
Cataldi M, Perez-Reyes E, Tsien RW
IN:
J Biol Chem
2002; 277(48):45969-45976
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: Pore size is of considerable interest in voltage-gated Ca(2+) channels because they exemplify a fundamental ability of certain ion channels: to display large pore diameter, but als... Click HERE for details
(Journal Article): Molecular studies of the asymmetric pore structure of the human cardiac voltage-dependent Ca2+ channel.
Klockner U, Mikala G, Schwartz A, Varadi G
IN:
J Biol Chem
1996; 271(37):22293-22296
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: Proton transfer to calcium channels results in rapid fluctuations between two non-zero conductance levels when the current is carried by monovalent cations. A combination of site-d... Click HERE for details
(Journal Article): Differential contribution by conserved glutamate residues to an ion-selectivity site in the L-type Ca2+ channel pore.
Mikala G, Bahinski A, Yatani A, Tang S, Schwartz A
IN:
FEBS Lett
1993; 335(2):265-269
Impact Factor(s) of FEBS Lett: 3.843 (2004), 3.609 (2003), 3.912 (2002), 3.644 (2001)
ABSTRACT: In voltage-gated cation channels, it is thought that residues responsible for ion-selectivity are located within the pore-lining SS1-SS2 segments. In this study, we compared the io... Click HERE for details
(Journal Article): Architecture of Ca(2+) channel pore-lining segments revealed by covalent modification of substituted cysteines.
Koch SE, Bodi I, Schwartz A, Varadi G
IN:
J Biol Chem
2000; 275(44):34493-34500
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: The cysteine accessibility method was used to explore calcium channel pore topology. Cysteine mutations were introduced into the SS1-SS2 segments of Motifs I-IV of the human cardia... Click HERE for details
(Journal Article): Voltage sensor movements.
Bezanilla F
IN:
J Gen Physiol
2002; 120(4):465-473
Impact Factor(s) of J Gen Physiol: 5.105 (2004), 5.12 (2003), 5.477 (2001)
ABSTRACT: The voltage dependence of K+, Na+, and Ca2+ channels is brought about by a voltage sensor that moves 12–13 e0 across the entire electric field (Schoppa et al., 1992; Hirschberg e... Click HERE for details
(Journal Article): The principle of gating charge movement in a voltage-dependent K+ channel.
Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R
IN:
Nature
2003; 423(6935):42-48
Impact Factor(s) of Nature: 29.273 (2005), 32.182 (2004), 30.979 (2003), 30.432 (2002), 27.955 (2001)
ABSTRACT: The steep dependence of channel opening on membrane voltage allows voltage-dependent K+ channels to turn on almost like a switch. Opening is driven by the movement of gating charge... Click HERE for details
(Journal Article): Subunits of purified calcium channels.
De Jongh KS, Warner C, Catterall WA
IN:
J Biol Chem
1990; 265(25):14738-14741
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: Polyacrylamide gel electrophoresis of purified rabbit skeletal muscle L-type calcium channel before and after reduction of disulfide bonds confirmed that 27- and 24-kDa forms of th... Click HERE for details
(Journal Article): Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit.
Qin N, Yagel S, Momplaisir ML, Codd EE, D'Andrea MR
IN:
Mol Pharmacol
2002; 62(3):485-496
Impact Factor(s) of Mol Pharmacol: 5.8 (2004), 5.65 (2003), 5.48 (2002), 5.297 (2001)
ABSTRACT: The voltage-gated calcium channel is composed of a pore-forming alpha(1) subunit and several regulatory subunits: alpha(2)delta, beta, and gamma. We report here the identification ... Click HERE for details
(Journal Article): Use of transgenic mice to study voltage-dependent Ca2+ channels.
Muth JN, Varadi G, Schwartz A
IN:
Trends Pharmacol Sci
2001; 22(10):526-532
Impact Factor(s) of Trends Pharmacol Sci: 13.054 (2004), 13.965 (2003), 13.276 (2002), 11.394 (2001)
ABSTRACT: During the past decade a great number of genes encoding high- and low-voltage-dependent Ca(2+) channels and their accessory subunits have been cloned. Studies of Ca(2+) channel str... Click HERE for details
(Journal Article): Molecular basis for Ca2+ channel diversity.
Hofmann F, Biel M, Flockerzi V
IN:
Annu Rev Neurosci
1994; 17(1):399-418
Impact Factor(s) of Annu Rev Neurosci: 24.184 (2005), 23.143 (2004), 30.167 (2003), 24.091 (2002), 27.152 (2001)
ABSTRACT: n/a Click HERE for details
(Journal Article): Acceleration of activation and inactivation by the beta subunit of the skeletal muscle calcium channel.
Varadi G, Lory P, Schultz D, Varadi M, Schwartz A
IN:
Nature
1991; 352(6331):159-162
Impact Factor(s) of Nature: 29.273 (2005), 32.182 (2004), 30.979 (2003), 30.432 (2002), 27.955 (2001)
ABSTRACT: The L-type voltage-dependent calcium channel is an important link in excitation-contraction coupling of muscle cells (reviewed in refs 2 and 3). The channel has two functional char... Click HERE for details
(Journal Article): Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.
Sutton KG, Martin DJ, Pinnock RD, Lee K, Scott RH
IN:
Br J Pharmacol
2002; 135(1):257-265
Impact Factor(s) of Br J Pharmacol: 3.325 (2004), 3.611 (2003), 3.45 (2002), 3.502 (2001)
ABSTRACT: 1. This study examined the action of gabapentin (gabapentin,1-(aminomethyl) cyclohexane acetic acid (Neurontin) on voltage-gated calcium (Ca(2+)) channel influx recorded in culture... Click HERE for details
(Journal Article): Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.
Marais E, Klugbauer N, Hofmann F
IN:
Mol Pharmacol
2001; 59(5):1243-1248
Impact Factor(s) of Mol Pharmacol: 5.8 (2004), 5.65 (2003), 5.48 (2002), 5.297 (2001)
ABSTRACT: High-voltage activated calcium channels are modulated by a series of auxiliary proteins, including those of the alpha(2)delta family. Until recently, only a single alpha(2)delta su... Click HERE for details
(Journal Article): Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin.
Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR
IN:
J Pharmacol Exp Ther
2002; 303(3):1199-1205
Impact Factor(s) of J Pharmacol Exp Ther: 4.335 (2004), 4.337 (2003), 3.555 (2001)
ABSTRACT: The calcium channel alpha2delta-1 subunit is a structural subunit important for functional calcium channel assembly. In vitro studies have shown that this subunit is the binding si... Click HERE for details
(Journal Article): Cerebellar ataxia, seizures, premature death, and cardiac abnormalities in mice with targeted disruption of the Cacna2d2 gene.
Ivanov SV, Ward JM, Tessarollo L, McAreavey D, Sachdev V, Fananapazir L, Banks MK, Morris N, Djurickovic D, Devor-Henneman DE, Wei MH, Alvord GW, Gao B, Richardson JA, Minna JD, Rogawski MA, Lerman MI
IN:
Am J Pathol
2004; 165(3):1007-1018
Impact Factor(s) of Am J Pathol: 6.441 (2004), 6.946 (2003), 6.75 (2002), 7.103 (2001)
ABSTRACT: CACNA2D2 is a putative tumor suppressor gene located in the human chromosome 3p21.3 region that shows frequent allelic imbalances in lung, breast, and other cancers. The alpha2delt... Click HERE for details
(Journal Article): Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.
Abernethy DR, Soldatov NM
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J Pharmacol Exp Ther
2002; 300(3):724-728
Impact Factor(s) of J Pharmacol Exp Ther: 4.335 (2004), 4.337 (2003), 3.555 (2001)
ABSTRACT: The L-type Ca2+ channels mediate depolarization-induced influx of Ca2+ into a wide variety of cells and thus play a central role in triggering cardiac and smooth muscle contraction... Click HERE for details
(Journal Article): Auxiliary subunits: essential components of the voltage-gated calcium channel complex
Arikkath J, Campbell KP
IN:
Curr Opin Neurobiol
2003; 13(3):298-307
Impact Factor(s) of Curr Opin Neurobiol: 7.937 (2004), 9.727 (2003), 10.718 (2002), 9.995 (2001)
ABSTRACT: Voltage-gated calcium channels are important mediators of several physiological processes, including neuronal excitability and muscle contraction. At the molecular level, the chann... Click HERE for details
(Journal Article): Gamma subunit of voltage-activated calcium channels.
Kang MG, Campbell KP
IN:
J Biol Chem
2003; 278(24):21315-21318
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT: Voltage-activated Ca2+ channels play a major role in many fundamental physiological processes including neurotransmission, muscle contraction, intracellular signaling, hormone secr... Click HERE for details
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