51. (Journal Article): Imbalance in Th Cell Polarization and its Relevance in Type 1 Diabetes Mellitus

Sia C
 
ABSTRACT: Functional polarization of T helper (Th) subsets of lymphocytes has been implicated in promoting or conferring risk to Type 1 diabetes mellitus (T1DM) development in human and diab...

52. (Journal Article): A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription fac-tors and is associated with susceptibility to type I diabetes mel-litus.

Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D
 
ABSTRACT: Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance protein stability and act...

53. (Journal Article): The C-174G promoter polymorphism of the interleukin-6 (IL-6) gene that affects insulin sensitivity in Caucasians is not involved in the pathogenesis of Taiwanese type 2 diabetes mellitus

Chang YH, Huang CN, Shiau MY
 
ABSTRACT: Interleukin-6 (IL-6) is a pleiotropic cytokine which regulates the immune response, the acute-phase response, hematopoiesis and body energy balance. Genetic polymorphism at -174 po...

54. (Journal Article): cFLIP protein prevents tumor necrosis factor-mediated induction of caspase-8-dependent apoptosis in insulin-secreting betaTc-Tet cells.

Cottet S, Dupraz P, Hamburger F, Dolci W, Jaquet M, Thorens B
 
ABSTRACT: Type 1 diabetes is characterized by the infiltration of activated leukocytes within the pancreatic islets, leading to beta-cell dysfunction and destruction. The exact role played b...

55. (Journal Article): Incretin mimetics as emerging treatments for type 2 diabetes.

Joy SV, Rodgers PT, Scates AC
 
ABSTRACT: OBJECTIVE: To review the physiology, pharmacology, and clinical efficacy of glucagon-like peptide (GLP-1) and the incretin mimetics exenatide and liraglutide in clinical studies. D...

56. (Journal Article): Microvascular Complications in Cystic Fibrosis-Related Diabetes Mellitus: a Case Report.

Scott AIR, Clarke BE, Healy H, D'Emden M, Bell SC
 
ABSTRACT: CONTEXT, The prevalence of cystic fibrosis-related diabetes mellitus is increasing and is associated with increased survival from cystic fibrosis. CASE REPORT, This study describes...

57. (Journal Article): Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice.

Daniel D, Gill RG, Schloot N, Wegmann D
 
ABSTRACT: T cells are known to play an important role in beta cell destruction in the nonobese diabetic (NOD) mouse model of Type I diabetes and islet-specific T cell clones have been demons...

58. (Journal Article): The Influence of Physicians' Practice Management Strategies and Financial Arrangements on Quality of Care Among Patients With Diabetes

Keating NL, Landrum MB, Landon BE, Ayanian JZ, Borbas C, Wolf R, Guadagnoli E
 
ABSTRACT: CONTEXT:: Health care organizations use many strategies to influence physician behavior and the care delivered, but the effect of such strategies on quality is not known. OBJECTIVE...

59. (Journal Article): The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes

Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J, Lane CR, Schaffner SF, Bolk S, Brewer C, Tuomi T, Gaudet D, Hudson TJ, Daly M, Groop L, Lander ES
 
ABSTRACT: Genetic association studies are viewed as problematic and plagued by irreproducibility. Many associations have been reported for type 2 diabetes, but none have been confirmed in mu...

60. (Journal Article): Clinical outcomes and insulin secretion after islet transplantation with the Edmonton Protocol.

Ryan EA, Lakey JR, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliot JF, Bigam D, et al
 
ABSTRACT: Islet transplantation offers the prospect of good glycemic control without major surgical risks. After our initial report of successful islet transplantation, we now provide furthe...