31. (Journal Article): No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo.

Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF
 
ABSTRACT: Several recent studies have suggested that the adult bone marrow harbors cells that can differentiate into tissues from all three germ layers. Other reports have contradicted these...

32. (Journal Article): Histologic differentiation of human fetal pancreatic explants transplanted into nude mice.

Tuch BE, Ng AB, Jones A, Turtle JR
 
ABSTRACT: The transplantation of human fetal pancreas has been suggested as a means of treatment of insulin-dependent diabetes in man. We have obtained human fetal pancreata during the secon...

33. (Journal Article): Characterization of a nuclear-factor-kappa B (NFkappaB) genetic marker in type 1 diabetes (T1DM) families.

Gylvin T, Bergholdt R, Nerup J, Pociot F
 
ABSTRACT: Cytokine-induced beta-cell death is an important factor in the pathogenesis of type 1 diabetes mellitus (T1DM). The transcription factor NFkappaB plays an important role in cytokin...

34. (Journal Article): Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.

Kosoy R, Concannon P
 
ABSTRACT: Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk fo...

35. (Journal Article): Genes Mediating Environment Interactions in Type 1 Diabetes

Biros E, Jordan MA, Baxter AG
 
ABSTRACT: The relative risk of type 1 (autoimmune) diabetes mellitus for a sibling of an affected patient is fifteen times that of the general population, indicating a strong genetic contrib...

36. (Journal Article): Type 1 Diabetes and NKT Cells: A Report on the 3rd International Workshop on NKT Cells and CD1-Mediated Antigen Presentation, September 2004, Heron Island, QLD, Australia

Fletcher JM, Jordan MA, Baxter AG
 
ABSTRACT: NKT cells play a major role in regulating the vigor and character of a broad range of immune responses. Defects in NKT cell numbers and function have been associated with type 1 di...

37. (Journal Article): Cholesterol Emboli Syndrome in Type 2 Diabetes: The Disease History of a Case Evaluated with Renal Scintigraphy

Piccoli GB, Sargiotto A, Burdese M, Colla L, Bilucaglia D, Magnano A, Consiglio V, Piccoli G, Picciotto G
 
ABSTRACT: BACKGROUND: Cholesterol crystal emboli syndrome (CCE) is an emerging disease, whose progression reflects the currently observed increase in cardiovascular diseases. Diagnostic crit...

38. (Journal Article): Type 2 Diabetes – Failure, Blame and Guilt in the Adoption of Insulin Therapy

Phillips P
 
ABSTRACT: Type 2 Diabetes is a progressive disease with an insidious onset, including decreased first-phase insulin secretion and mild forms of hyperinsulinemia caused by heterogenous factor...

39. (Journal Article): Sustained proliferation of PDX-1 (+) cells derived from human islets.

Beattie GM, Itkin-Ansari P, Cirulli V, Leibowitz G, Lopez AD, Bossie S, Mally MI, Levine F, Hayek A
 
ABSTRACT: Ex vivo expansion of human beta-cells is an important step toward the development of cell-based insulin delivery systems in type 1 diabetes. Here, we report that human pancreatic e...

40. (Journal Article): Characterization and isolation of promoter-defined nestin-positive cells from the human fetal pancreas.

Humphrey RK, Bucay N, Beattie GM, Lopez A, Messam CA, Cirulli V, Hayek A
 
ABSTRACT: Studies using adult human islets and mouse embryonic stem cells have suggested that the neurepithelial precursor cell marker nestin also identifies and can be used to purify beta-c...