41. (Journal Article): Analysis and Optimization of Nutritional Set-up for Murine Pancreatic Acinar Cells.

Kurup S, Bhonde RR
 
ABSTRACT: CONTEXT: Pancreatic acinar cell cultivation poses a serious problem due to limitations in the in vitro survival time despite variations of dissociation protocols, culture media and...

42. (Journal Article): Islet Generation from Intra Islet Precursor Cells of Diabetic Pancreas: In Vitro Studies Depicting In Vivo Differentiation

Banerjee M, Bhonde RR
 
ABSTRACT: CONTEXT: Beta-cells have a limited replicative capacity; hence, there is always a quest for sources of islet regeneration to compensate for the loss of functional beta-cells in dia...

43. (Journal Article): Shell-Less Chick Embryo Culture as an Alternative in vitro Model to Investigate Glucose-Induced Malformations in Mammalian Embryos

Datar S, Bhonde RR
 
ABSTRACT: We have developed a simple shell-less chick embryo culture system to study glucose-induced malformations. This system involves the culturing of chick embryos from the second day to...

44. (Journal Article): Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets.

Abernethy DR, Soldatov NM
 
ABSTRACT: The L-type Ca2+ channels mediate depolarization-induced influx of Ca2+ into a wide variety of cells and thus play a central role in triggering cardiac and smooth muscle contraction...

45. (Journal Article): Adherence to Guidelines and its Effects on Hospitalizations with Complications of Type 2 Diabetes

Sloan FA, Bethel MA, Lee PP, Brown DS, Feinglos MN
 
ABSTRACT: OBJECTIVES: To study the discrepancy between actual and recommended rates of use among several measures of screening for complications of diabetes in a national longitudinal sample...

46. (Journal Article): Epithelial-to-mesenchymal transition generates proliferative human islet precursor cells.

Gershengorn MC, Hardikar AA, Wei C, Geras-Raaka E, Marcus-Samuels B, Raaka BM
 
ABSTRACT: Insulin-expressing beta cells, found in pancreatic islets, are capable of generating more beta cells even in the adult. We show that fibroblast-like cells derived from adult human ...

47. (Journal Article): Neuroendocrine immuno-ontogeny of the pathogenesis of autoimmune disease in the nonobese diabetic (NOD) mouse.

Homo-Delarche F
 
ABSTRACT: Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which insulin-producing beta cells of the pancreatic islets of Langerhans are destroyed. The nonobese diabetic (NOD...

48. (Journal Article): Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets

Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R
 
ABSTRACT: Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if differentiated cell types can be derived from them and u...

49. (Journal Article): Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosis.

Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W
 
ABSTRACT: Interleukin (IL)-10 and transforming growth factor (TGF)-beta1 are suppressor cytokines that frequently occur together during a regulatory T cell response. Here we used a one gene ...

50. (Journal Article): Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta.

Nakamura K, Kitani A, Strober W
 
ABSTRACT: CD4(+)CD25(+) T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4(+)CD25(-) T cells by cell-cell contact and not secretion of...