11. (Journal Article): The concept of space and competition in immune regulation.

Stockinger B, Barthlott T, Kassiotis G
 
ABSTRACT: Not availabe

12. (Journal Article): Concordance for type 2 (non-insulin-dependent) diabetes mellitus in male twins

Newman B, Selby JV, King MC, Slemenda C, Fabsitz R, Friedman GD
 
ABSTRACT: Concordance for Type 2 (non-insulin-dependent) diabetes was determined in 250 monozygotic and 264 dizygotic white male twin pairs who participated in the National Heart, Lung, and ...

13. (Journal Article): A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance

Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, Shen GQ, Mott D, Knowler WC, Cox NJ, Horikawa Y, Oda N, Bell GI, Bogardus C
 
ABSTRACT: Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was...

14. (Journal Article): Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage.

Amrani A, Durant S, Throsby M, Coulaud J, Dardenne M, Homo-Delarche F
 
ABSTRACT: Because few data were available on glucose homeostasis at the early prediabetic stage in the nonobese diabetic (NOD) mouse, we investigated glycemia, insulinemia, and pancreatic in...

15. (Journal Article): Proteins of the bcl-2 family in apoptosis signaling: from mechanistic insights to therapeutic opportunities.

Chan SL, Yu VC
 
ABSTRACT: 1. Proteins of the Bcl-2 family are central regulators of apoptosis and are thought to act primarily on the mitochondria. 2. Members of the Bcl-2 family possess either anti-apoptot...

16. (Journal Article): IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells.

Vieira PL, Christensen JR, Minaee S, O'Neill EJ, Barrat FJ, Boonstra A, Barthlott T, Stockinger B, Wraith DC, O'Garra A
 
ABSTRACT: Regulatory T cells (T(Reg)) control immune responses to self and nonself Ags. The relationship between Ag-driven IL-10-secreting T(Reg) (IL-10-T(Reg)) and naturally occurring CD4(+...

17. (Journal Article): Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers.

Almeida AR., Legrand N, Papiernik M, Freitas A
 
ABSTRACT: We show that the lymphoid hyperplasia observed in IL-2Ralpha- and IL-2-deficient mice is due to the lack of a population of regulatory cells essential for CD4 T cell homeostasis. I...

18. (Journal Article): IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage.

O'Garra A, Vieira PL, Vieira P, Goldfeld AE
 
ABSTRACT: Effective immune responses against pathogens are sometimes accompanied by strong inflammatory reactions. To minimize damage to self, the activation of the immune system also trigge...

19. (Journal Article): Treatment of type 1 diabetes mellitus with DAB486-IL2, a toxin conjugate witch targets activated T-lymphocytes

Boitard C, Timsit J, Assan R, Mogenet A, Debussche X, Kaloustlan E, Attali JR, Chanson P, Chatenoud L, Woodworth T, et al.
 
ABSTRACT: Evidence point to autoreactive T-Iymphocytes in the pathogenesis of insulin-¬dependent diabetes mellitus (IDDM). Treatment with Cyclosporin A (7.5-10 mg/kg/d) of IDDM patients ind...

20. (Journal Article): "Persistence of Diabetes" - Why Has Research into Type 1 Diabetes not Made Significant Advances?

Sia C, Weinem M
 
ABSTRACT: n/a