(Journal Article): The effect of alpha 1-blocking vasodilator on fetal growth and uteroplacental blood flow in streptozotocin-induced diabetic rats.
 
Takenaka Y, Toyoda N (Department of Obstetrics and Gynecology, Mie University School of Medicine, Japan.)
 
IN: Life Sci 1995; 56(13):1127-1134
Impact Factor(s) of Life Sci: 2.158 (2004), 1.944 (2003), 1.824 (2002), 1.758 (2001)

Fulltext:    HTML  PDF

ABSTRACT: For largely unknown reasons, severe diabetes mellitus in pregnant rats results in fetal growth retardation. In order to clarify the mechanism of this phenomenon, the relationship between the fetal growth and the uteroplacental blood flow, and the fetal serum insulin and IGF-1 concentrations were studied in streptozotocine-induced diabetic and control pregnant rats. As compared to control rats, diabetic rats had significantly reduced uteroplacental blood flow, and the mean body weight of the fetuses was significantly lower. Treatment of diabetic rats with an alpha1-blocking vasodilator, urapidil, restored uteroplacental blood flow and fetal body weight without affecting hyperglycemia. There was no significant difference between diabetic and normal rats with respect to insulin and IGF-1 concentrations in fetal plasma, although the mean value was slightly lower in the diabetic. We conclude that reduced uteroplacental blood flow is a major factor in the establishment of fetal growth retardation in diabetic pregnancies.

TYPE OF PUBLICATION: Original article

Articles citing this article:

• Mammon K, Keshet R, Savion S, Pekar O, Zaslavsky Z, Fein A, Toder V, Torchinsky A. Diabetes-Induced Fetal Growth Retardation is Associated with Suppression of NF-κB Activity in Embryos. Rev Diabetic Stud 2005. 2: 27-34.
  » Diabetes OD » Diabetic Complications » Risk of Diabetes » Diabetic Embryopathy/Fetal Gro... » Retardation » Disturbances in Protein and Ge... » NF-κB Expression » Journal Article