|
|
|
(Journal Article): Placental insufficiency and its consequences.
Gagnon R (Departments of Obstetrics, Gynecology and Physiology, University of Western Ontario, St. Joseph's Health Care London, 268 Grosvenor Street, London, Ont., Canada N6A 4V2.,
rgagnon@uwo.ca
)
IN:
Eur J Obstet Gynecol Reprod Biol
2003; 110 Suppl:S99-107
Impact Factor(s) of Eur J Obstet Gynecol Reprod Biol: 0.955 (2004), 1.002 (2003), 0.884 (2001)
Fulltext:
HTML
PDF
ABSTRACT: Placental insufficiency is a process leading to progressive deterioration in placental function and a decrease in transplacental transfer of oxygen and nutrients to the fetus. The resulting fetal hypoxemia is the major stimulus involved in the reduction in fetal growth as an attempt to reduce metabolic demands by the growing fetus. Fetal growth restriction (FGR) is the second cause of perinatal death after prematurity and can complicate up to 6% of all pregnancies. It is becoming apparent that its occurrence has major impacts on the fetus and placenta with consequences on the cardiovascular, metabolic and neurological development up to adulthood. We are just starting to unveil some of the basic mechanisms involved in this complex adaptation that may lead to reprogramming of fetal organs development mostly the heart, pancreas, lungs and brain. It is becoming clear that future research is needed to develop strategies to improve antenatal detection of FGR, in addition to reduce the risk of abnormal neurodevelopment during childhood, and onset of common diseases in adulthood following pregnancies complicated with placental insufficiency.
TYPE OF PUBLICATION: Review
Articles citing this article:
|
Respond
on this Journal Article!
Hint: Your Response should directly apply to Placental insufficiency and its consequences..
Please check, if this context applies best to your contribution. Otherwise click HERE to change to the appropriate
subject area. The actual subject area is Placental Anomalies.
|
|
|
|
|
