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Polymorphism
(Journal Article): Functional variants in SUMO4, TAB2, and NFkappaB and the risk of type 1 diabetes.
Kosoy R, Concannon P
IN:
Genes Immun
2005; 6(3):231-235
Impact Factor(s) of Genes Immun: 3.718 (2004), 3.637 (2003), 3.06 (2002), 3.787 (2001)
ABSTRACT:
Several functional genetic variants that can potentially modulate the activity of NFkappaB have been recently described. As reduced NFkappaB activity has been implicated in risk fo...
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(Journal Article): SUMO wrestling with type 1 diabetes.
Li M, Guo D, Isales CM, Eizirik DL, Atkinson M, She JX, Wang CY
IN:
J Mol Med
2005; 83(7):504-513
ABSTRACT:
Post-translational modification of proteins by phosphorylation, methylation, acetylation, or ubiquitylation represent central mechanisms through which various biological processes ...
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(Journal Article): A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY
IN:
Nat Genet
2004; 36(8):837-841
Impact Factor(s) of Nat Genet: 25.797 (2005), 24.695 (2004), 26.494 (2003), 26.711 (2002), 29.6 (2001)
ABSTRACT:
Previous studies have suggested more than 20 genetic intervals that are associated with susceptibility to type 1 diabetes (T1D), but identification of specific genes has been chall...
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(Journal Article): A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription fac-tors and is associated with susceptibility to type I diabetes mel-litus.
Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D
IN:
J Biol Chem
2004; 279(26):27233-27238
Impact Factor(s) of J Biol Chem: 6.355 (2004), 6.482 (2003), 7.258 (2001)
ABSTRACT:
Three SUMO (small ubiquitin-related modifier) genes have been identified in humans, which tag proteins to modulate subcellular localization and/or enhance protein stability and act...
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(Journal Article): Assessing the validity of the association be-tween the SUMO4 M55V variant and risk of type 1 diabetes.
Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA.
IN:
Nat Genet
2005; 37(2):110-111
Impact Factor(s) of Nat Genet: 25.797 (2005), 24.695 (2004), 26.494 (2003), 26.711 (2002), 29.6 (2001)
ABSTRACT:
Not available.
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(Journal Article): Additional support for a genetic association between SUMO4 and type 1 diabetes in the Korean population.
Park Y, Park S, Kang J, et al
IN:
Additional support for a ge-netic association between SUMO4 and type 1 diabetes in the Korean population
Nat Genet (in press).:-
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(Journal Article): Genetic heterogeneity of the IDDM5 (SUMO4) locus.
Wang CY, Yang P, She JX
IN:
Nat Genet
:-
Impact Factor(s) of Nat Genet: 25.797 (2005), 24.695 (2004), 26.494 (2003), 26.711 (2002), 29.6 (2001)
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