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(Journal Article): Beta cell apoptosis in T cell-mediated autoimmune diabetes.
Kurrer MO, Pakala SV, Hanson HL, Katz JD (Department of Pathology, Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.)
IN:
Proc Natl Acad Sci U S A
1997; 94(1):213-218
Impact Factor(s) of Proc Natl Acad Sci U S A: 10.452 (2004), 10.272 (2003), 10.7 (2002), 10.896 (2001)
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ABSTRACT: Insulin-dependent diabetes mellitus results from T cell-mediated destruction of insulin-producing, pancreatic islet beta cells. How this destruction takes place has remained elusive--largely due to the slow kinetics of disease progression. By crossing a transgenic mouse carrying a beta cell-specific T cell receptor onto the NOD.scid background, we produced a simplified but robust and accelerated model of diabetes. This mouse produces CD4+ T cells bearing transgenic T cell receptor but is devoid of CD8+ T cells and B cells. More importantly, this mouse develops a rapid diabetes, which has allowed us to record and quantify beta cell death. We have determined that beta cells within the inflamed islets die by apoptosis.
TYPE OF PUBLICATION: Original article
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